CAJ | 학술논문

目的：探讨Ki-67抗原在人脑星形细胞肿瘤中的表达及其对预后的意义。方法：原发性星形细胞瘤89例。使用S-P免疫组化方法检测手术切除标本石蜡块的Ki-67抗原，并算得Ki-67指数。生存分析单因素使用Kaplan-Meier法计算生存率并采用logrank(对数秩)检验。多因素分析使用COX比例风险模型，采用逐步回归分析。结果：Ki-67 LI在组织学分级GradeⅡ、Ⅲ、Ⅳ中分别为2.67%±1.62%，6. 71%±3.89%，8.07%±3.84%。三组间有显著性差异(P<0.01)。单因素分析结果显示组织学分级、Ki-67指数等因素与患者预后有关(logrank<0.01)。在GradeⅡ中，K i-67指数>2.5%与GradeⅢ中Ki-67指数≤2.5%的患者生存期差异无显著性(P>0. 05)；在GradeⅣ中，Ki-67指数≤2.5%与>2.5%的患者生存期有显著性差异(P<0 .01)。结论：Ki-67指数随着各病理级别增高而增高；Ki-67指数>2.5%提示预后较差。在同一病理级别中，Ki-67指数不同，其预后有显著性差异。联合利用组织病理检查及K i-67指数检测有助于更精确地判断预后。
목적：탐토Ki-67항원재인뇌성형세포종류중적표체급기대예후적의의。 방법：원발성성형세포류89례。사용S-P면역조화방법검측수술절제표본석 사괴적Ki-67항원，병산득Ki-67지수。생존분석단인소사용Kaplan-Meier법계산생존솔병채 용logrank(대수질)검험。다인소분석사용COX비례풍험모형，채용축보회귀분석。결과：Ki-67 LI재조직학분급GradeⅡ、Ⅲ、Ⅳ중분별위2.67%±1.62%，6. 71%±3.89%，8.07%±3.84%。삼조간유현저성차이(P<0.01)。단인소분석결과 현시조직학분급、Ki-67지수등인소여환자예후유관(logrank<0.01)。재GradeⅡ중，K i-67지수>2.5%여GradeⅢ중Ki-67지수≤2.5%적환자생존기차이무현저성(P>0. 05)；재GradeⅣ중，Ki-67지수≤2.5%여>2.5%적환자생존기유현저성차이(P<0 .01)。결론：Ki-67지수수착각병리급별증고이증고；Ki-67지수>2.5%제시예후교 차。재동일병리급별중，Ki-67지수불동，기예후유현저성차이。연합이용조직병리검사급K i-67지수검측유조우경정학지판단예후。
Objective:To explore the prognostic factors for patients with astroc ytic tumors and to determine the value of Ki-67 labeling index obtained using MI B-1 monoclonal antibody in predicting survival.Methods:Data of 89 patients with astrocytic tumors were collected en rolled in Nantoing Medical College affiliated hospital from 1994 to 1996.Ki-67 w as determined with immunohistochemistry using monoclonal antibody MIB-1.For the univariate analysis,survival probabilities were estimated based on Kaplan-Meier 's Product-Limit Survival Estimates method and logrank test was used to assess THe association between patient survival and each variable.Multivariate regressio n analysis using Cox's proportional-hazards model was used to ascertain a simult aneous effect of outcome-related variables on survival.Results:the mean Ki-67 LIs were 2.67%±1.62% in GradeⅡ,6.74%±3.89% in GradeⅢ and 8.07%±3.84% in GradeⅣ.Analysis of variance indicated a signifi cant difference among them.Univariate analysis showed thaTHistologic grade and Ki-67 LI were significant factors for survival.Conclusion:There is a strong positive relationship between Ki-67 LI and histologic grade.The higher histologic grade,the higher Ki-67 LI.And Ki-67 L I>2.5% is a significant factor for shorter survival.In the same histologic grade ,there is a significant difference in patients' prognosis due to the different K i-67 LI.Whereas,with the different Ki-67 LI,some patients with differenTHistolo gic grade have no significant survival time.Ki-67 LI and histologic grade detect ed together will provide more accurate useful information for determining the pa tients' prognosis.