CAJ | 학술논문

为了探讨预防型抗氟剂(Ⅰ型-1)的遗传毒性，选用雄性昆明种小白鼠30只，随机分为阴性对照组、低、中、高剂量组(剂量分别为200，400，800 mg/kg)、阳性对照组(环磷酰胺50 mg/kg)。剂量组灌胃，每天一次，连续5天。断头取血，进行微核试验和单细胞凝胶电泳实验(SCGE)。结果表明，剂量组不但微核率较低，而且也未出现彗星。提示，预防型抗氟剂(Ⅰ型-1)在200～800 mg/kg 剂量范围内对小鼠无遗传毒性。
위료탐토예방형항불제(Ⅰ형-1)적유전독성，선용웅성곤명충소백서30지，수궤분위음성대조조、저、중、고제량조(제량분별위200，400，800 mg/kg)、양성대조조(배린선알50 mg/kg)。제량조관위，매천일차，련속5천。단두취혈，진행미핵시험화단세포응효전영실험(SCGE)。결과표명，제량조불단미핵솔교저，이차야미출현혜성。제시，예방형항불제(Ⅰ형-1)재200～800 mg/kg 제량범위내대소서무유전독성。
In order to study the genetic toxicity of preventive anti-fluorine agent(Ⅰ-1)，30 mice of Kunmin species were selected and divided into 5 groups,namely negative test group,low dose group(200 mg/kg)，medium does group(400 mg/kg),high dose group(800 mg/kg),and positive test group (cytozan 50 mg/kg).The dose groups were fed with anti-fluorine agent(Ⅰ-1)once a day successively for 5 days.Then they were killed for blood SCGE test and micronucleus test.The results showed that the micronucleus rate was comparatively low with no comet rate in the dose groups.It suggests that the preventive anti-fluorine agent(Ⅰ-1)in the dose range of 200～800 mg/kg might not have genetic toxicity to mice.