CAJ | 학술논문

目的动态观察脑梗死患者血清腐胺、精脒、精胺水平变化。方法选择16例脑梗死患者及26例正常人，应用高效液相色谱法测定血清腐胺、精脒、精胺水平。结果脑梗死患者发病7天内腐胺水平显著升高并达峰值，7天后开始下降，14天后仍明显高于对照组；精脒、精胺水平7天内显著低于对照组，7天后恢复并逐渐达对照组水平。脑梗死急性期腐胺水平随病情加重显著升高，精脒、精胺水平随病情加重而下降。结论聚胺代谢紊乱参与了脑梗死的病理生理过程。
목적동태관찰뇌경사환자혈청부알、정미、정알수평변화。방법선택16례뇌경사환자급26례정상인，응용고효액상색보법측정혈청부알、정미、정알수평。결과뇌경사환자발병7천내부알수평현저승고병체봉치，7천후개시하강，14천후잉명현고우대조조；정미、정알수평7천내현저저우대조조，7천후회복병축점체대조조수평。뇌경사급성기부알수평수병정가중현저승고，정미、정알수평수병정가중이하강。결론취알대사문란삼여료뇌경사적병리생리과정。
Objective To study the changes in levels of serum polyamines in the patients with cerebral infarction. Methods Serum putrescine,spermidine and spermine were measured by using HPLC in 16 cases of cerebral infarction and 26 controls. Results The levels of serum putrescine in the patients with cerebral infarction were increased as compared with those in the control group. The level of serum putrescine reached its peak within 7 days,began to decrease from the 7th day and higher than in the control group after 14 days. The levels of serum spermidine and spermine in the patients with cerebral infarction were significantly decreased as compared with those in the control group within 7 days,gradually recovered and returned to that in the control group after 7 days. The severer the condition of cerebral infarction,the higher the putrescine level and the lower the spermidine and spermine levels. Conclusion Polyamines metabolic disturbance plays a major role in pathophysiological and pathogenetic mechanisms of cerebral infarction.