CAJ | 학술논문

目的:探讨卵巢癌腹腔化疗药物的药代动力学特征.方法:10例原发性卵巢上皮性癌患者,手术后1周行以DDP+5-FU为主的腹腔化疗, 剂量为DDP 60 mg/m2,5-FU 750 mg/m2.于腹腔注射完毕后0.5、1、2、6、24小时分别取血样,用HPLC及原子吸收光谱法分别测定血清5-FU和总铂浓度.数据以药代动力学软件3P87处理.结果:腹腔注射后,5-FU、DDP血清平均浓度的变化过程符合一级吸收的单室药代动力学模型.其参数分别为:5-FU:Ke = 0.45±0.18 /h、Ka = 7.59±4.63 /h、T(peak) = 0.87±0.30 h、C(max) = 2.46±1.12 μg/ml、AUC = 8.38±4.71 蘥*h/ml、Vd=316±69.4 ml/kg;DDP:Ke = 0.014±0.01 /h、Ka = 1.31±1.03 /h、T(peak) = 4.72±2.81 h、C(max) = 0.85±0.28 μg/ml、AUC = 85.6±55.7 μg*h/ml 、Vd = 60.3±32.6 ml/kg.5-FU,AUC0～24h = 8.4 μg*h/ml;DDP,AUC0～24h = 14.4 μg*h/ml.结论:从药代动力学方面看,腹腔化疗中5-FU的AUC不低于相同剂量静脉给药,DDP的AUC低于相同剂量静脉给药.Ζ
목적:탐토란소암복강화료약물적약대동역학특정.방법:10례원발성란소상피성암환자,수술후1주행이DDP+5-FU위주적복강화료, 제량위DDP 60 mg/m2,5-FU 750 mg/m2.우복강주사완필후0.5、1、2、6、24소시분별취혈양,용HPLC급원자흡수광보법분별측정혈청5-FU화총박농도.수거이약대동역학연건3P87처리.결과:복강주사후,5-FU、DDP혈청평균농도적변화과정부합일급흡수적단실약대동역학모형.기삼수분별위:5-FU:Ke = 0.45±0.18 /h、Ka = 7.59±4.63 /h、T(peak) = 0.87±0.30 h、C(max) = 2.46±1.12 μg/ml、AUC = 8.38±4.71 약*h/ml、Vd=316±69.4 ml/kg;DDP:Ke = 0.014±0.01 /h、Ka = 1.31±1.03 /h、T(peak) = 4.72±2.81 h、C(max) = 0.85±0.28 μg/ml、AUC = 85.6±55.7 μg*h/ml 、Vd = 60.3±32.6 ml/kg.5-FU,AUC0～24h = 8.4 μg*h/ml;DDP,AUC0～24h = 14.4 μg*h/ml.결론:종약대동역학방면간,복강화료중5-FU적AUC불저우상동제량정맥급약,DDP적AUC저우상동제량정맥급약.Ζ