CAJ | 학술논문

目的为研究我国哈萨克族与汉族维生素D受体基因多态性分布与骨质疏松的关系. 方法采用聚合酶链反应（PCR）限制性片段长度多态性技术，对哈萨克族（年龄50±2岁）的健康妇女93例，和汉族（年龄59±3岁）健康妇女179例进行VDR基因检测. 结果在中国哈萨克族93例中，bb型44例（47%），Bb型45例（48%），BB型4例（4%）；在汉族179例中，bb型162例（90%），Bb型17例（10%），未见BB型. 结论中国哈萨克族VDR基因多态性分布与汉族相比存在非常显著性差异（P<0.005）.
목적위연구아국합살극족여한족유생소D수체기인다태성분포여골질소송적관계. 방법채용취합매련반응（PCR）한제성편단장도다태성기술，대합살극족（년령50±2세）적건강부녀93례，화한족（년령59±3세）건강부녀179례진행VDR기인검측. 결과재중국합살극족93례중，bb형44례（47%），Bb형45례（48%），BB형4례（4%）；재한족179례중，bb형162례（90%），Bb형17례（10%），미견BB형. 결론중국합살극족VDR기인다태성분포여한족상비존재비상현저성차이（P<0.005）.
AIM　To explore the difference between Kazakh and the Han in the distribution of vitamin D receptor(VDR) gene polymorphism. METHODS　 VDR genotypes in 179 health postmenopausal women of the Han nationality (age:59±3 years),and in 93 those of the Kazakh (age: 50±2 years),and also in 17cases of osteoporosis patients were analyzes by polymerase chain reaction restriction fragment length polymorphism. RESULTS　Frequencies of bb,Bb and BB genotype are 90%,10% and 0% in the the Han,and 47%,48% and 4% in the Kazakh respectively. A significant difference is found in the frequency distribution of VDR genotype between the Han and the Kazakh (P<0.005). CONCLUSION　Han and Kazakh differ in the frequency distribution of VDR genotype.