CAJ | 학술논문

[目的]研究结核病合并慢性乙肝患者血清肿瘤坏死因子-α(TNF-α)、γ干扰素(IFN-γ)及白细胞介素-12(IL-12)水平的变化及意义.[方法]肺结核并HBsAg阳性患者21例(A组),单纯肺结核患者30例(B组),健康对照组30例(C组).应用酶联免疫吸附法(ELISA)测定三组血清中TNF-α、IFN-γ、IL-12浓度水平.[结果]A组和B组TNF-α水平均高于C组(P<0.01) ;但A组T组和B组之间TNF-α水平差异无显著性(P>0.05);B组IFN-γ、IL-12水平均低于C组(P<0.05);而A组IFN-γ、IL-12水平均低于B组(P<0.05).[结论]在结核病合并慢性乙肝患者的体内,可能存在着显著的Th1细胞免疫应答减弱.
[목적]연구결핵병합병만성을간환자혈청종류배사인자-α(TNF-α)、γ간우소(IFN-γ)급백세포개소-12(IL-12)수평적변화급의의.[방법]폐결핵병HBsAg양성환자21례(A조),단순폐결핵환자30례(B조),건강대조조30례(C조).응용매련면역흡부법(ELISA)측정삼조혈청중TNF-α、IFN-γ、IL-12농도수평.[결과]A조화B조TNF-α수평균고우C조(P<0.01) ;단A조T조화B조지간TNF-α수평차이무현저성(P>0.05);B조IFN-γ、IL-12수평균저우C조(P<0.05);이A조IFN-γ、IL-12수평균저우B조(P<0.05).[결론]재결핵병합병만성을간환자적체내,가능존재착현저적Th1세포면역응답감약.
[Objective] To investigate the serum levels of TNF-α, IFN-γ, IL-12 in patients with pulmonary tuberculosis complicated with hepatitis B virus(HBV). [Methods]Serum levels of TNF-α, IFN-γ and IL-12 in patients with pulmonary tuberculosis patients complicated with HBV and healthy controls were studied by ELISA. [Results]Serum levels of TNF-α in patients with pulmonary tuberculosis complicated with HBV were higher than those in healthy group(P<0.01). The serum levels of IFN-γ and IL-12 in patients with pulmonary tuberculosis were lower than those in healthy group (P<0.05). Serum levels of IFN-γ and IL-12 in patients with pulmonary tuberculosis were lower than those in patients with pulmonary tuberculosis complicated with HBV (P<0.05). [Conclusion] Patients with pulmonary tuberculosis complicated with HBV may present the obvious decreasing of Th1 cellular immunologic response.