CAJ | 학술논문

成熟的microRNA(miRNA)是一种长约22 nt的非编码RNA,通过与靶基因的3'非翻译区(3'UTR)结合来调控靶基因的表达.直至目前,在不同物种中发现的miRNA达6 397个.miRNA的发现为基因表达调控研究打开了新的窗口.目前研究者不仅证实miRNA在生物体生长、发育和疾病发生等过程中发挥着重要的作用,而且开始进一步探寻其发挥作用的分子机理.综述了miRNA与细胞信号转导途径之间的关系,从而有助于从基因水平上理解疾病的发生机制,为疾病的诊断、治疗提供依据.
성숙적microRNA(miRNA)시일충장약22 nt적비편마RNA,통과여파기인적3'비번역구(3'UTR)결합래조공파기인적표체.직지목전,재불동물충중발현적miRNA체6 397개.miRNA적발현위기인표체조공연구타개료신적창구.목전연구자불부증실miRNA재생물체생장、발육화질병발생등과정중발휘착중요적작용,이차개시진일보탐심기발휘작용적분자궤리.종술료miRNA여세포신호전도도경지간적관계,종이유조우종기인수평상리해질병적발생궤제,위질병적진단、치료제공의거.
Mature miRNAs is a sort of non coding RNA about 19-25 nt in length,which can complement to the target mRNA by binding to the region of 3' UTR and then regulate their expression.To date,about 6 397 miRNAs have been fund among different species,the discovery of which opens a new window for the research of gene expression.At present,the researchers not only confirmed that miRNAs play an important role in growth,development,and occurrence of diseases,and also began to exploring the molecular mechanism of miRNAs.This paper summarized relationship between miRNAs and the signaling pathway,thus,provide the basis for disease diagnosis and therapy.