CAJ | 학술논문

在温和条件下,Zn(OTf)_2能有效催化氯化苄对对氯苯酚的C-苄基化反应,选择性合成杀菌剂2-苄基-4-氯苯酚(BCP),合成的优化条件为n(对氯苯酚):n(氯化苄)=1.2:1,催化剂Zn(OTf)_2对氯化苄摩尔分数为5%,60 ℃下反应6 h,用硝基甲烷为溶剂,氯化苄转化率和产物BCP的产率分别＞99%和94%.
재온화조건하,Zn(OTf)_2능유효최화록화변대대록분분적C-변기화반응,선택성합성살균제2-변기-4-록분분(BCP),합성적우화조건위n(대록분분):n(록화변)=1.2:1,최화제Zn(OTf)_2대록화변마이분수위5%,60 ℃하반응6 h,용초기갑완위용제,록화변전화솔화산물BCP적산솔분별＞99%화94%.
C-Benzylation of 4-chlorophenol(BCP) was selectively perpared via the catalysis of Zn(OTf)_2 under mild conditions with an excellent yield. The optimum reaction conditions included that the molar ratio of the reactants (4-chlorophol:benzyl chloride) was 1.2:1,5% Zn(OTf)_2(molar ratio),and 6 h agitation at 60 ℃ in nitromethane. The conversion of 4-chlorophenol and selectivity of BCP were ＞99% and 94%,respectively under the conditions.