CAJ | 학술논문

目的探讨蛛网膜下腔出血(SAH)后多层螺旋CT灌注成像(MS-CTP)评价区域脑灌注减低的应用价值.方法将32只清洁级雄性日本大耳白兔随机分成两组,其中A组(正常组)8只,B组(SAH组)24只.采用枕大池二次注血法构建兔SAH模型,在造模后第7天行MS-CTP扫描.原始数据通过灌注分析软件获得两侧额顶及基底节的平均脑血流量(CBF)灌注参数图.并于MS-CTP扫描结束后立即处死、取脑,观察SAH情况.结果两组实验动物额部(t=1.740,P=0.092)、顶部(t=1.868,P=0.072)平均CBF值差异无统计学意义,基底节区差异有统计学意义(t=2.481,P=0.O19).B组实验动物兔基底池可见血凝块分布,而额、顶部未见血凝块存在.结论MS-CTP能够监测SAH后兔脑微循环灌注的变化,并得出区域脑灌注减低与血凝块的分布有关,从而指导SAH后脑灌注减低的早期诊断,有利于临床进行早期的干预治疗.
목적 탐토주망막하강출혈(SAH)후다층라선CT관주성상(MS-CTP)평개구역뇌관주감저적응용개치.방법 장32지청길급웅성일본대이백토수궤분성량조,기중A조(정상조)8지,B조(SAH조)24지.채용침대지이차주혈법구건토SAH모형,재조모후제7천행MS-CTP소묘.원시수거통과관주분석연건획득량측액정급기저절적평균뇌혈류량(CBF)관주삼수도.병우MS-CTP소묘결속후립즉처사、취뇌,관찰SAH정황.결과 량조실험동물액부(t=1.740,P=0.092)、정부(t=1.868,P=0.072)평균CBF치차이무통계학의의,기저절구차이유통계학의의(t=2.481,P=0.O19).B조실험동물토기저지가견혈응괴분포,이액、정부미견혈응괴존재.결론MS-CTP능구감측SAH후토뇌미순배관주적변화,병득출구역뇌관주감저여혈응괴적분포유관,종이지도SAH후뇌관주감저적조기진단,유리우림상진행조기적간예치료.
Objective To explore the chiaical value of cerebral perfusion reduction after subarachnoid hemorrhage(SAH)by multi spiral CT perfusion in rabbits.Methods 32 male Japanese big-ear rabbits of clean level were randomly divided into 2 groups:Group A(n =8),the normal group,were to obtain normal MS-CTP values of rabbit cerebrums;Group B(n =24),the SAH group was made into two-hemorrhage animal models,checked on seven day by multi spiral CT perfusion.The source data was transmitted to the post-processing workstation ADW 4.2.Perfusion parameters maps(CBF)of both sides of frontal,parietal and basal ganglia were got by computing.Each rabbit was killed immediately after scanning,and the spider blood was observed.Results The average CBF value of the two groups:The difference was not statistically significant at the frontal(t =1.740,P =0.092)and parietal(t =1.868,P =0.072); The average values of CBF were significantly decreased at the basal ganglia(t =2.481,P =0.019).Group B showed the distribution of blood clot in the basal cistern,but there was no blood clot at the frontal and parietal.Conclusion The monitor perfusion changes of rabbit brain after SAH could be detected by MS-CTP,and the lower of regional cerebral perfusion had a relationship with the distribution with the blood clot,and it could instruct the early diagnosis of cerebral perfusion,and the clinical benefit to early intervention treatment.