CAJ | 학술논문

目的探讨急性有机磷农药中毒特效解毒药物的最佳应用时机及剂量,以提高治愈率.方法采用随机分组的方法,把我院救治的1192例急性有机磷农药中毒患者分为两组,实验组560例,阿托品的应用方法是快速消除中毒症状后停药观察,待再出现轻微中毒症状时再次应用阿托品;氯磷定仅应用1~2 d.对照组632例采用传统治疗方法,达到传统阿托品化标准后维持一段时间,逐渐减量,直至停用阿托品.收集两组氯磷定和阿托品应用时间、应用总量、住院天数和不良反应等资料,并对两组资料进行统计学分析.结果实验组几乎无尿潴留、烦躁不安和呼吸衰竭等不良反应的发生,解毒药物的应用时间及总量亦明显少于对照组,大部分患者24 h即可不再应用解毒药物且经观察无反跳病例发生.结论新的应用方法在急性有机磷农药中毒治疗中能明显提高治愈率、缩短住院时间、减少过量应用阿托品及氯磷定造成的不良反应.
목적 탐토급성유궤린농약중독특효해독약물적최가응용시궤급제량,이제고치유솔.방법 채용수궤분조적방법,파아원구치적1192례급성유궤린농약중독환자분위량조,실험조560례,아탁품적응용방법 시쾌속소제중독증상후정약관찰,대재출현경미중독증상시재차응용아탁품;록린정부응용1~2 d.대조조632례채용전통치료방법,체도전통아탁품화표준후유지일단시간,축점감량,직지정용아탁품.수집량조록린정화아탁품응용시간、응용총량、주원천수화불량반응등자료,병대량조자료진행통계학분석.결과 실험조궤호무뇨저류、번조불안화호흡쇠갈등불량반응적발생,해독약물적응용시간급총량역명현소우대조조,대부분환자24 h즉가불재응용해독약물차경관찰무반도병례발생.결론 신적응용방법 재급성유궤린농약중독치료중능명현제고치유솔、축단주원시간、감소과량응용아탁품급록린정조성적불량반응.
Objective To study the best timing and dosage of detoxification application for acute organophosphorus pesticide poisoning for the improvement of cure rate. Methods One thousand one hundred and ninety-two cases of acute organophosphorus pesticide poisoning, treated in our hospital, were included and randomly divided into two groups. For the 560 cases in the experimental group, application of atropine was withdrawn when poisoning symptoms were observed to disappear rapidly. When mild symptoms appeared, atropine was applied again. Pyraloxime methylchloride was used for only 1-2 days. Six hundred and thirty-two cases in the control group were treated with traditional methods until atropinization and then lasted for several days, and gradually reduced until withdrawal. Information collected included application time, application dose, length of stay and adverse reaction of pyraloxime methylchloride and atropine. Two sets of data were analyzed statistically. Results Uretention, irritability, respiratory failure and other adverse reactions did not occur in the experimental group. Application time and total dose of the detoxification drug was also significantly less than the control group. Most patients could no longer be applied with detoxification drug after 24 hours and no rebound occurred after observation. Conclusions The application of new methods in the acute organophosphorus pesticide poisoning treatment can significantly improve the cure rate, shorten hospital stay and reduce adverse reactions that are caused by application of atropine and pyraloxime methylchloride excessively.