中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2004年
31期
7060-7061
,共2页
脑梗塞%内皮缩血管肽1%内皮生长因子
腦梗塞%內皮縮血管肽1%內皮生長因子
뇌경새%내피축혈관태1%내피생장인자
背景:内皮素-1(endothelin-1,ET-1)和血管内皮细胞生长因子(vascular endothelial growthfactor,VEGF)在蛋白及核酸水平方面的研究多见于动物实验,而ET-1和VEGF与临床脑梗死病变方面关系的研究还未广泛开展.目的:探讨脑梗死发病中ET-1和VEGF的变化规律及机制.设计:完全随机对照研究.地点和对象:选自2000-03/06中国医科大学第二临床学院神经内科住院脑梗死患者27例及同期在本院正常体检老年人22例.干预:患者先行头CT或MRI检查,发病第3天及4周抽取肘静脉血,分别采用放免法及ELISA法测定血浆中ET-1和血清中VEGF含量.主要观察指标:血浆中ET-1和血清中VEGF含量.结果:脑梗死组ET-1及VEGF含量[(65.7±10.8)ng/L,(419.5±176.3)ng/L]均高于对照组[(48.8±6.9)ng/L,(205.7±101.8)ng/L],两组比较差异有显著性意义(t=2.015,P＜0.05,t=2.705,P＜0.01);到恢复期时有所下降[ET-1含量为(60.2±11.5)ng/L, VEGF含量为(309.4±138.9)ng/L],与对照组比较,差异有显著性意义(t=2.028,P＜0.05;t=2.724,P＜0.01).ET-1及VEGF含量与梗死灶的大小及病情程度有关.结论:ET-1及VEGF与脑梗死的发生、发展密切相关,从而为脑卒中预防及康复干预提供实验依据.
揹景:內皮素-1(endothelin-1,ET-1)和血管內皮細胞生長因子(vascular endothelial growthfactor,VEGF)在蛋白及覈痠水平方麵的研究多見于動物實驗,而ET-1和VEGF與臨床腦梗死病變方麵關繫的研究還未廣汎開展.目的:探討腦梗死髮病中ET-1和VEGF的變化規律及機製.設計:完全隨機對照研究.地點和對象:選自2000-03/06中國醫科大學第二臨床學院神經內科住院腦梗死患者27例及同期在本院正常體檢老年人22例.榦預:患者先行頭CT或MRI檢查,髮病第3天及4週抽取肘靜脈血,分彆採用放免法及ELISA法測定血漿中ET-1和血清中VEGF含量.主要觀察指標:血漿中ET-1和血清中VEGF含量.結果:腦梗死組ET-1及VEGF含量[(65.7±10.8)ng/L,(419.5±176.3)ng/L]均高于對照組[(48.8±6.9)ng/L,(205.7±101.8)ng/L],兩組比較差異有顯著性意義(t=2.015,P＜0.05,t=2.705,P＜0.01);到恢複期時有所下降[ET-1含量為(60.2±11.5)ng/L, VEGF含量為(309.4±138.9)ng/L],與對照組比較,差異有顯著性意義(t=2.028,P＜0.05;t=2.724,P＜0.01).ET-1及VEGF含量與梗死竈的大小及病情程度有關.結論:ET-1及VEGF與腦梗死的髮生、髮展密切相關,從而為腦卒中預防及康複榦預提供實驗依據.
배경:내피소-1(endothelin-1,ET-1)화혈관내피세포생장인자(vascular endothelial growthfactor,VEGF)재단백급핵산수평방면적연구다견우동물실험,이ET-1화VEGF여림상뇌경사병변방면관계적연구환미엄범개전.목적:탐토뇌경사발병중ET-1화VEGF적변화규률급궤제.설계:완전수궤대조연구.지점화대상:선자2000-03/06중국의과대학제이림상학원신경내과주원뇌경사환자27례급동기재본원정상체검노년인22례.간예:환자선행두CT혹MRI검사,발병제3천급4주추취주정맥혈,분별채용방면법급ELISA법측정혈장중ET-1화혈청중VEGF함량.주요관찰지표:혈장중ET-1화혈청중VEGF함량.결과:뇌경사조ET-1급VEGF함량[(65.7±10.8)ng/L,(419.5±176.3)ng/L]균고우대조조[(48.8±6.9)ng/L,(205.7±101.8)ng/L],량조비교차이유현저성의의(t=2.015,P＜0.05,t=2.705,P＜0.01);도회복기시유소하강[ET-1함량위(60.2±11.5)ng/L, VEGF함량위(309.4±138.9)ng/L],여대조조비교,차이유현저성의의(t=2.028,P＜0.05;t=2.724,P＜0.01).ET-1급VEGF함량여경사조적대소급병정정도유관.결론:ET-1급VEGF여뇌경사적발생、발전밀절상관,종이위뇌졸중예방급강복간예제공실험의거.
BACKGROUND:The animal experimental research on changing rules of the endothelin-1 (ET-1) and the vascular endothelial growth factor(VEGF) is more than that in protein and nucleic acid level, however, the research of relationship between ET-1 and VEGF in clinical pathologic change of cerebral infarction has not yet been studied.OBJECTIVE: To investigate the changing rules and the mechanism of ET-1and VEGF in cerebral infarction.DESIGN: A completely randomized case-control study.SETTING and PARTICIPANTS: Twenty-seven hospitalized patients with cerebral infarction in Neurology Department of Second Hospital of China Medical University and 22 senior citizens having health examination were selected from March to June in 2000 .INTERVENTIONS: CT or MRI of head was performed first, and the blood of elbow vein was taken on the third day and 4 weeks after onset. The content of ET-1 in the plasm and VEGF in the blood serum were tested with radioimmunoassay and enzyme-linked immunosorbent assay(ELISA).MAIN OUTCOME MEASURES: The content of ET-1 in plasma and the content of VEGF in blood serum.RESULTS: The contents of ET-1 and VEGF[ (65.7 ± 10. 8) ng/L and (419.5 ± 176.3) ng/L] in cerebral infarction group were higher than that in control group[ (48.8 ± 6.9) ng/L and (205.7 ± 101.8) ng/L], and there was a significant difference between the two groups( t =2. 015, P < 0.05;t = 2. 705, P < 0.01 ) ); The contents of ET-1 and VEGF were decreased in the convalescence phase[the content of ET-1 was(60. 2 ± 11.5) ng/L; the content of VEGF was(309.4 ± 138.9) ng/L], and there was a significant difference compared to that in the control group (t = 2. 028, P < 0. 05;t = 2. 724, P<0. 01 ). The contents of ET-1 and VEGF were related with the infarct focal size and the state of illness.CONCLUSION: ET-1 and VEGF are closely related with the occurrence and development of cerebral infarction,thus it provides the experimental basis for the prevention and rehabilitation intervention of stroke.
