中国癌症防治杂志
中國癌癥防治雜誌
중국암증방치잡지
CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT
2009年
2期
148-150
,共3页
华蟾素%鼻咽肿瘤%肿瘤/放射疗法
華蟾素%鼻嚥腫瘤%腫瘤/放射療法
화섬소%비인종류%종류/방사요법
Cinobufacin%Nasopharyngeal neoplasm%Radiotherapy
目的 探讨华蟾素在鼻咽癌放射治疗中的作用.方法 2004年5月至2006年5月对我院68例鼻咽癌随机分别采用放疗联合华蟾素(研究组)和单纯放疗(对照组)治疗,放疗方法 相同,放疗过程中急性反应按RTOG/EORTC标准记录,治疗结束和结束后3个月评价疗效.结果 放疗结束时研究组和对照组有效率(RR)分别为85.29%(29/34)和73.53%(25/34),两组差异无统计学意义(χ2= 0.810,P=0.368).对获部分缓解(PR)以上效果的患者进一步分析,其中放疗结束时研究组和对照组淋巴结转移灶完全缓解率(CR)分别为69.0%和45.6%(P=0.0627);放疗后3月CR分别为82.8%和52.0%(χ2=4.549,P=0.0329).口咽黏膜反应2级以上对照组有30例,研究组21例,组间比较差异有统计学意义(χ2=6.472,P=0.039);皮肤反应、血小板和血红蛋白指标无明显差异.结论 华蟾索对提高鼻咽癌淋巴结转移灶控制率和减轻放疗急性反应都有一定的效果,但其远期疗效有待进一步随访及研究.
目的 探討華蟾素在鼻嚥癌放射治療中的作用.方法 2004年5月至2006年5月對我院68例鼻嚥癌隨機分彆採用放療聯閤華蟾素(研究組)和單純放療(對照組)治療,放療方法 相同,放療過程中急性反應按RTOG/EORTC標準記錄,治療結束和結束後3箇月評價療效.結果 放療結束時研究組和對照組有效率(RR)分彆為85.29%(29/34)和73.53%(25/34),兩組差異無統計學意義(χ2= 0.810,P=0.368).對穫部分緩解(PR)以上效果的患者進一步分析,其中放療結束時研究組和對照組淋巴結轉移竈完全緩解率(CR)分彆為69.0%和45.6%(P=0.0627);放療後3月CR分彆為82.8%和52.0%(χ2=4.549,P=0.0329).口嚥黏膜反應2級以上對照組有30例,研究組21例,組間比較差異有統計學意義(χ2=6.472,P=0.039);皮膚反應、血小闆和血紅蛋白指標無明顯差異.結論 華蟾索對提高鼻嚥癌淋巴結轉移竈控製率和減輕放療急性反應都有一定的效果,但其遠期療效有待進一步隨訪及研究.
목적 탐토화섬소재비인암방사치료중적작용.방법 2004년5월지2006년5월대아원68례비인암수궤분별채용방료연합화섬소(연구조)화단순방료(대조조)치료,방료방법 상동,방료과정중급성반응안RTOG/EORTC표준기록,치료결속화결속후3개월평개료효.결과 방료결속시연구조화대조조유효솔(RR)분별위85.29%(29/34)화73.53%(25/34),량조차이무통계학의의(χ2= 0.810,P=0.368).대획부분완해(PR)이상효과적환자진일보분석,기중방료결속시연구조화대조조림파결전이조완전완해솔(CR)분별위69.0%화45.6%(P=0.0627);방료후3월CR분별위82.8%화52.0%(χ2=4.549,P=0.0329).구인점막반응2급이상대조조유30례,연구조21례,조간비교차이유통계학의의(χ2=6.472,P=0.039);피부반응、혈소판화혈홍단백지표무명현차이.결론 화섬색대제고비인암림파결전이조공제솔화감경방료급성반응도유일정적효과,단기원기료효유대진일보수방급연구.
Objective To explore the therapeutic effects of cinobufacin combined with radiotherapy on nasopharyngeal carcinoma (NPC).Methods 68 NPC patients from May 2003 to May 2005 were assigned randomly into the study group and control group.Both groups were treated with the same radiotherapy,but the treatment in study group was combined with cinobufacin.Acute side effects of radiotherapy were assessed according to the RTOG (radiation therapy oncology group) standard,and the curative effects were evaluated at the end of the treatment and at the third month after treatment.Results At the end of treatment,the local response rates in the study group and the control group were 85.29% (29/34) and 73.53% (25/34) respectfully,the difference between the two groups was not significant (χ2= 0.810,P=0.368).But the result from further analysis on the patients with the responses more than partial remission showed the complete remission rates of lymph node metastasis in study group and control group were 69.0% and 45.6% respectively at the end of treatment (P=0.0627),and 52.0% and 82.8% respectively at the third month after treatment (χ2=4.549,P=0.0329).The side effects of acute skin-mucosal that serious more than grade 2 was significantly different (χ2=6.472,P=0.039) between the study group (10 cases) and control group (21 cases).There was no statistically significant difference between the two groups on skin response,platelet and hemoglobin decreases.Conclusion s Cinobufacin can enhance the control rate of lymph node metastasis and reduce the incidence of acute side effects of radiotherapy.Further follow-up study on its long-term effect is necessary.
