CAJ | 학술논문

目的:观察平贝母水提物、雪花梨汁以及平贝雪梨饮(BLY)的抗炎作用及其作用机制.方法:通过二甲苯导致小鼠耳肿胀实验、鸡蛋清敛大鼠足趾肿胀实验及对小鼠毛细血管通透性的影响分别观察平贝母水提物、雪花梨及BLY的抗炎作用,同时通过测定小鼠炎性渗出物中前列腺素(PGE_2)和丙二醛(MDA)含量研究三者的抗炎机制.结果:三者均能减轻二甲苯所致的耳廓肿胀;能降低小鼠毛细血管通透性;能减轻鸡蛋清致大鼠足趾肿胀;能抑制小鼠炎性渗出物中PGE:和MDA含量的升高,且梨汁和BLY均与PGE2和MDA含量呈量效关系.结论:平贝母水提物和雪花梨汁都具有抗炎作用,同等剂量的BLY作用效果比平贝母水提物和雪花梨汁抗炎作用之和更为显著,三者对PGE_2和MDA含量升高具有负调节作用,提示其抗炎作用与抗PGE_2和MDA含量升高有关.
목적:관찰평패모수제물、설화리즙이급평패설리음(BLY)적항염작용급기작용궤제.방법:통과이갑분도치소서이종창실험、계단청렴대서족지종창실험급대소서모세혈관통투성적영향분별관찰평패모수제물、설화리급BLY적항염작용,동시통과측정소서염성삼출물중전렬선소(PGE_2)화병이철(MDA)함량연구삼자적항염궤제.결과:삼자균능감경이갑분소치적이곽종창;능강저소서모세혈관통투성;능감경계단청치대서족지종창;능억제소서염성삼출물중PGE:화MDA함량적승고,차리즙화BLY균여PGE2화MDA함량정량효관계.결론:평패모수제물화설화리즙도구유항염작용,동등제량적BLY작용효과비평패모수제물화설화리즙항염작용지화경위현저,삼자대PGE_2화MDA함량승고구유부조절작용,제시기항염작용여항PGE_2화MDA함량승고유관.
Objective: To investigate anti-inflammatory effects and action mechanisms of aqueous extract of Fritillaria ussuriensis Maxim., snow pear juice and Pingbei Xueli Yin (BLY). Methods: Animal models of auricular edema induced by xylene in mice, capillary permeability induced by acetic acid in mice and paw edema induced by albumen in rats were established to observe anti-inflammatory effects of aqueous extract of Fritillaria ussuriensis Maxim, snow pear juice and BLY. The contents of PGE_2 and MDA in inflammatory exudates were measured to explore anti-inflammatory mechanisms of three samples. Results: Aqueous extract of Fritillaria ussuriensis Maxim., snow pear juice and BLY exhibited good attenuation effects on auricular edema induced by xylene, paw edema induced by albumen and permeability increase of capillary induced by acetic acid. Meanwhile, the three experimental samples revealed an obvious inhibition effect on the increase of PGE_2 and MDA. Moreover, snow pear juice and BLY exhibited an obvious dose-dependent inhibition effect on the increase of PGE_2 and MDA. Conclusion: All of them have a good anti-inflammatory effect. A synergistic effect of Fritillaria ussuriensis Maxim. and snow pear juice on anti-inflammation is achieved. The three administration samples all had a negative regulation function on the level of PGE_2 and MDA, which suggests that the anti-inflammatory effect might be related to the reduction of PGE_2 and MDA levels.