中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2010年
10期
732-734
,共3页
刘颖%李伶%王毅%杨刚毅%陈文雯%董靖%李仁哲%杨艳%程伟%龙敏
劉穎%李伶%王毅%楊剛毅%陳文雯%董靖%李仁哲%楊豔%程偉%龍敏
류영%리령%왕의%양강의%진문문%동정%리인철%양염%정위%룡민
Chemerin%糖尿病,2型%高血压
Chemerin%糖尿病,2型%高血壓
Chemerin%당뇨병,2형%고혈압
Chemerin%Diabetic mellitus, Type 2% Hypertension
目的 探讨初诊2型糖尿病(T2DM)合并高血压患者血浆Chemerin水平变化及其与血压、WHR、血糖、血脂、血浆胰岛素水平等的关系.方法 酶联免疫法测定了初诊T2DM患者(T2DM组)、T2DM合并高血压患者(T2DM+HT组)和正常人(NGT组)血浆Chemerin水平,分析其与血压、BMI、WHR、血脂、HOMA-IR等的关系.结果 T2DM+HT组血浆Chemerin水平明显高于T2DM组和NGT组.血浆Chemerin水平与年龄、体重、腰围、臀围、DBP、体内脂肪百分比(FAT%)、BMI、WHR、TG、FFA、FPG、2hPG、FIns、2hPIns、HOMA-IR、HbA1c呈正相关.多元回归分析结果表明腰围、DBP、2hPIns、HbA1c是影响血浆Chemerin水平的独立相关因素.结论 血浆Chemerin水平的改变与糖脂代谢和血压等有关,并可能参与了胰岛素抵抗及糖尿病合并高血压的发生发展.
目的 探討初診2型糖尿病(T2DM)閤併高血壓患者血漿Chemerin水平變化及其與血壓、WHR、血糖、血脂、血漿胰島素水平等的關繫.方法 酶聯免疫法測定瞭初診T2DM患者(T2DM組)、T2DM閤併高血壓患者(T2DM+HT組)和正常人(NGT組)血漿Chemerin水平,分析其與血壓、BMI、WHR、血脂、HOMA-IR等的關繫.結果 T2DM+HT組血漿Chemerin水平明顯高于T2DM組和NGT組.血漿Chemerin水平與年齡、體重、腰圍、臀圍、DBP、體內脂肪百分比(FAT%)、BMI、WHR、TG、FFA、FPG、2hPG、FIns、2hPIns、HOMA-IR、HbA1c呈正相關.多元迴歸分析結果錶明腰圍、DBP、2hPIns、HbA1c是影響血漿Chemerin水平的獨立相關因素.結論 血漿Chemerin水平的改變與糖脂代謝和血壓等有關,併可能參與瞭胰島素牴抗及糖尿病閤併高血壓的髮生髮展.
목적 탐토초진2형당뇨병(T2DM)합병고혈압환자혈장Chemerin수평변화급기여혈압、WHR、혈당、혈지、혈장이도소수평등적관계.방법 매련면역법측정료초진T2DM환자(T2DM조)、T2DM합병고혈압환자(T2DM+HT조)화정상인(NGT조)혈장Chemerin수평,분석기여혈압、BMI、WHR、혈지、HOMA-IR등적관계.결과 T2DM+HT조혈장Chemerin수평명현고우T2DM조화NGT조.혈장Chemerin수평여년령、체중、요위、둔위、DBP、체내지방백분비(FAT%)、BMI、WHR、TG、FFA、FPG、2hPG、FIns、2hPIns、HOMA-IR、HbA1c정정상관.다원회귀분석결과표명요위、DBP、2hPIns、HbA1c시영향혈장Chemerin수평적독립상관인소.결론 혈장Chemerin수평적개변여당지대사화혈압등유관,병가능삼여료이도소저항급당뇨병합병고혈압적발생발전.
ObjectiveTo investigate the changes of plasma Chemerin level and the relationship between plasma Chemerin level and blood pressure, waist hip ratio (WHR), blood lipids, blood glucose, plasma insulin levels as well as other factors in newly diagnosed type 2 diabetic patients with hypertension.MethodsPlasma Chemerin levels were assayed by ELISA in the newly diagnosed type 2 diabetes mellitus (T2DM) , type 2 diabetic patients with hypertension (T2DM+HT) and normal controls (NC). The relationship between plasma Chemerin levels and blood pressure, BMI, WHR, blood lipids and HOMA-insulin resistance index (HOMA-IR ) as also analyzed.ResultsPlasma Chemerin level in T2DM+HT was significantly increased,as compared with T2DM and NC ［(74.6±6.4） vs （68.6±12.5 ）and （62.1±19.3)μg/L，both P<0.01］. Plasma Chemerin level correlated positively with age, body weight, waist circumference(WC), hip circumference, DBP,visceral fat%(FAT%), BMI, WHR, TG, FFA, FPG, 2hPG, FIns, 2hPIns, HOMA-IR, HbA1c（r=0.20, 0.25, 0.33, 0.20, 0.27, 0.30, 0.34, 0.24, 0.25, 0.16, 0.17, 0.21, 0.18, 0.21, 0.21, 0.19 ,respectively P<0.01 and P<0.05）.Multiple regression analysis showed that WC, DBP, 2hPINS, HbA1c were independent related factors influencing plasma Chemerin level.ConclusionsThe changes of Chemerin levels are associated with glucose and lipid metabolism and blood pressure, and it may contribute, in part, to the pathogenesis of IR and diabetes complicated with hypertension.
