白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2012年
3期
167-170
,共4页
李文克%李文倩%冯建明%艾国
李文剋%李文倩%馮建明%艾國
리문극%리문천%풍건명%애국
多发性骨髓瘤%C-反应蛋白%血红蛋白%红细胞沉降率%国际分期体系
多髮性骨髓瘤%C-反應蛋白%血紅蛋白%紅細胞沉降率%國際分期體繫
다발성골수류%C-반응단백%혈홍단백%홍세포침강솔%국제분기체계
Multiple myeloma%C-reactive protein%Hemoglobin%Erythrocyte sedimentation rate%International staging system
目的 探讨多发性骨髓瘤(MM)中C-反应蛋白( CRP)、血红蛋白(Hb)、红细胞沉降率( ESR)3项指标的变化及其临床意义.方法 选取新诊断的30例MM患者,记录首次入院的实验室检查指标及临床指标,行国际分期体系( ISS)分期.以同期住院的30例年龄、性别、Hb相仿的巨幼细胞贫血(MA)患者作为对照组.对比不同ISS分期MM中CRP、Hb、ESR的差异,并分析3个指标与肿瘤细胞比例、β2-微球蛋白( β2-MG)的相关性.结果 MM组Ⅲ期患者CRP、Hb、ESR分别为(24.17±9.87)mg/L、(71.72±13.27)g/L、( 105.94±27.73 )mm/h,Ⅰ、Ⅱ期分别为(8.54±1.97) mg/L、(91.00±9.92) g/L、( 67.00±15.56 )mm/h和(14.89 ±5.51 )mg/L、( 91.29±8.32) g/L、( 73.57±20.53) mm/h,Ⅲ期与Ⅰ、Ⅱ期比较,差异均有统计学意义(均P＜ 0.05).MM组CRP、ESR分别为(19.40± 10.17) mg/L、( 91.90±29.70) mm/h,MA组分别为(7.52±1.57)mg/L、( 20.20±8.04) mm/h,差异均有统计学意义(均P＜0.05).MM患者CRP、Hb、ESR与肿瘤细胞比例、β2-MG有一定相关性(均P＜0.05).结论 MM病情发展与CRP、Hb、ESR有密切关系,CRP、Hb相对ESR对疾病反应敏感,联合检测3项指标对于观察患者病情进展有明显的临床意义.
目的 探討多髮性骨髓瘤(MM)中C-反應蛋白( CRP)、血紅蛋白(Hb)、紅細胞沉降率( ESR)3項指標的變化及其臨床意義.方法 選取新診斷的30例MM患者,記錄首次入院的實驗室檢查指標及臨床指標,行國際分期體繫( ISS)分期.以同期住院的30例年齡、性彆、Hb相倣的巨幼細胞貧血(MA)患者作為對照組.對比不同ISS分期MM中CRP、Hb、ESR的差異,併分析3箇指標與腫瘤細胞比例、β2-微毬蛋白( β2-MG)的相關性.結果 MM組Ⅲ期患者CRP、Hb、ESR分彆為(24.17±9.87)mg/L、(71.72±13.27)g/L、( 105.94±27.73 )mm/h,Ⅰ、Ⅱ期分彆為(8.54±1.97) mg/L、(91.00±9.92) g/L、( 67.00±15.56 )mm/h和(14.89 ±5.51 )mg/L、( 91.29±8.32) g/L、( 73.57±20.53) mm/h,Ⅲ期與Ⅰ、Ⅱ期比較,差異均有統計學意義(均P＜ 0.05).MM組CRP、ESR分彆為(19.40± 10.17) mg/L、( 91.90±29.70) mm/h,MA組分彆為(7.52±1.57)mg/L、( 20.20±8.04) mm/h,差異均有統計學意義(均P＜0.05).MM患者CRP、Hb、ESR與腫瘤細胞比例、β2-MG有一定相關性(均P＜0.05).結論 MM病情髮展與CRP、Hb、ESR有密切關繫,CRP、Hb相對ESR對疾病反應敏感,聯閤檢測3項指標對于觀察患者病情進展有明顯的臨床意義.
목적 탐토다발성골수류(MM)중C-반응단백( CRP)、혈홍단백(Hb)、홍세포침강솔( ESR)3항지표적변화급기림상의의.방법 선취신진단적30례MM환자,기록수차입원적실험실검사지표급림상지표,행국제분기체계( ISS)분기.이동기주원적30례년령、성별、Hb상방적거유세포빈혈(MA)환자작위대조조.대비불동ISS분기MM중CRP、Hb、ESR적차이,병분석3개지표여종류세포비례、β2-미구단백( β2-MG)적상관성.결과 MM조Ⅲ기환자CRP、Hb、ESR분별위(24.17±9.87)mg/L、(71.72±13.27)g/L、( 105.94±27.73 )mm/h,Ⅰ、Ⅱ기분별위(8.54±1.97) mg/L、(91.00±9.92) g/L、( 67.00±15.56 )mm/h화(14.89 ±5.51 )mg/L、( 91.29±8.32) g/L、( 73.57±20.53) mm/h,Ⅲ기여Ⅰ、Ⅱ기비교,차이균유통계학의의(균P＜ 0.05).MM조CRP、ESR분별위(19.40± 10.17) mg/L、( 91.90±29.70) mm/h,MA조분별위(7.52±1.57)mg/L、( 20.20±8.04) mm/h,차이균유통계학의의(균P＜0.05).MM환자CRP、Hb、ESR여종류세포비례、β2-MG유일정상관성(균P＜0.05).결론 MM병정발전여CRP、Hb、ESR유밀절관계,CRP、Hb상대ESR대질병반응민감,연합검측3항지표대우관찰환자병정진전유명현적림상의의.
Objective To analyze the changes and clinical significance of C-reactive protein (CRP)、hemoglobin (Hb) and erythrocyte sedimentation rate (ESR) in different disease stage of multiple myeloma according the international staging system. Method Thirty untreated MM patients with complete clinical records were included in the stndy. The multiple myeloma patients were classified into three groups according to international staging system (ISS).Thirty megaloblastic anemia patients of similar age 、sex、hemoglobin level as the observation group.Resulets The levels of CRP (24.17±9.87 mg/L)、Hb (71.72±13.27 g/L) and ESR (105.94±27.73 mm/h) of stage Ⅲ patients were statistically different with stage Ⅰ ( CRP 8.54±1.97 mg/L; Hb 91.00±9.92g/L; ESR 73.57±20.53mm/h)、Ⅱ patients ( CRP 14.89±5.51 mg/L; Hb 91.29±8.32g/L; ESR 67.00± 15.56 mm/h) separately (P＜0.05).The levels of CRP (19.40±10.17 mg/L) and ESR (91.90±29.70 mm/h) in the MM patients were significantly higher than that in the observation group Ⅰ ( CRP 7.52±1.57mg/L; ESR 20.20±8.04mm/h) (P＜0.05 respectively).CRP and ESR level in MM patients positively correlated with myeloma cell proportion and β2-microglobulin level (P＜0.05), while Hb level negatively correlated with myeloma cell proportion and β2-microglobulin level (P＜0.05),Conclusion The levels of C-reactive protein、hemoglobin and erythrocyte sedimentation rate are closely associated with the development of multiple myeloma. C-reactive protein and hemoglobin are relatively sensitive response to disease than erythrocyte sedimentation rate. There is a clear clinical implication in detecting the patient' s condition for progress and the prognosis.
