中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
8期
627-630
,共4页
牛志宏%吴丹丹%谷瑞环%程美玉%吴铃%冯云
牛誌宏%吳丹丹%穀瑞環%程美玉%吳鈴%馮雲
우지굉%오단단%곡서배%정미옥%오령%풍운
多囊卵巢综合征%体重指数%氧化应激
多囊卵巢綜閤徵%體重指數%氧化應激
다낭란소종합정%체중지수%양화응격
Polycystic ovary syndrome%Body mass index%Oxidative stress
目的 探讨多囊卵巢综合征( PCOS)患者体重指数与卵泡液氧化应激指标活性氧簇(ROS)和总抗氧化能力(TAC)之间的相关性.方法 所有纳入者均为实施体外受精-胚胎移植助孕技术的不孕症患者.55例PCOS患者分为超重组(23例)和正常体重组(32例),55名年龄匹配月经正常的非PCOS妇女分为正常对照组(30名)和超重组(25名),测定血中基础性激素水平、总胆固醇、甘油三酯水平.在经过促排卵治疗后,取卵日测定卵泡液中ROS与TAC.结果 超重和超重PCOS组患者甘油三酯水平高于正常对照和正常体重PCOS组患者[分别为(1.9±1.1、1.7±0.9、1.0±0.5、1.2±0.7)mmol/L,均P＜0.05],超重和超重PCOS组患者总胆固醇水平高于正常对照组[分别为(4.8±1.2、5.2±1.1、4.0±0.6) mmol/L,均P＜0.05].与PCOS正常体重组及非PCOS女性相比,超重PCOS组患者,卵泡液内ROS和ROS/TAC分别为(35.4±6.7) RLU/S及39.8±22.0,均比其他3组患者明显升高,而TAC为(0.8±0.5)Mm,较其他3组明显下降(均P＜0.05).在正常体重女性,PCOS患者ROS/TAC高于非PCOS组(26.5±14.5对14.2±12.5,P＜0.05).PCOS患者卵泡液ROS、ROS/TAC均与体重指数呈正相关(r=0.34和r=0.32,均P＜0.05).结论 PCOS患者卵泡液内存在氧化应激状态的异常,且其异常状态与体重指数有正相关性.
目的 探討多囊卵巢綜閤徵( PCOS)患者體重指數與卵泡液氧化應激指標活性氧簇(ROS)和總抗氧化能力(TAC)之間的相關性.方法 所有納入者均為實施體外受精-胚胎移植助孕技術的不孕癥患者.55例PCOS患者分為超重組(23例)和正常體重組(32例),55名年齡匹配月經正常的非PCOS婦女分為正常對照組(30名)和超重組(25名),測定血中基礎性激素水平、總膽固醇、甘油三酯水平.在經過促排卵治療後,取卵日測定卵泡液中ROS與TAC.結果 超重和超重PCOS組患者甘油三酯水平高于正常對照和正常體重PCOS組患者[分彆為(1.9±1.1、1.7±0.9、1.0±0.5、1.2±0.7)mmol/L,均P＜0.05],超重和超重PCOS組患者總膽固醇水平高于正常對照組[分彆為(4.8±1.2、5.2±1.1、4.0±0.6) mmol/L,均P＜0.05].與PCOS正常體重組及非PCOS女性相比,超重PCOS組患者,卵泡液內ROS和ROS/TAC分彆為(35.4±6.7) RLU/S及39.8±22.0,均比其他3組患者明顯升高,而TAC為(0.8±0.5)Mm,較其他3組明顯下降(均P＜0.05).在正常體重女性,PCOS患者ROS/TAC高于非PCOS組(26.5±14.5對14.2±12.5,P＜0.05).PCOS患者卵泡液ROS、ROS/TAC均與體重指數呈正相關(r=0.34和r=0.32,均P＜0.05).結論 PCOS患者卵泡液內存在氧化應激狀態的異常,且其異常狀態與體重指數有正相關性.
목적 탐토다낭란소종합정( PCOS)환자체중지수여란포액양화응격지표활성양족(ROS)화총항양화능력(TAC)지간적상관성.방법 소유납입자균위실시체외수정-배태이식조잉기술적불잉증환자.55례PCOS환자분위초중조(23례)화정상체중조(32례),55명년령필배월경정상적비PCOS부녀분위정상대조조(30명)화초중조(25명),측정혈중기출성격소수평、총담고순、감유삼지수평.재경과촉배란치료후,취란일측정란포액중ROS여TAC.결과 초중화초중PCOS조환자감유삼지수평고우정상대조화정상체중PCOS조환자[분별위(1.9±1.1、1.7±0.9、1.0±0.5、1.2±0.7)mmol/L,균P＜0.05],초중화초중PCOS조환자총담고순수평고우정상대조조[분별위(4.8±1.2、5.2±1.1、4.0±0.6) mmol/L,균P＜0.05].여PCOS정상체중조급비PCOS녀성상비,초중PCOS조환자,란포액내ROS화ROS/TAC분별위(35.4±6.7) RLU/S급39.8±22.0,균비기타3조환자명현승고,이TAC위(0.8±0.5)Mm,교기타3조명현하강(균P＜0.05).재정상체중녀성,PCOS환자ROS/TAC고우비PCOS조(26.5±14.5대14.2±12.5,P＜0.05).PCOS환자란포액ROS、ROS/TAC균여체중지수정정상관(r=0.34화r=0.32,균P＜0.05).결론 PCOS환자란포액내존재양화응격상태적이상,차기이상상태여체중지수유정상관성.
Objective To study the relationship between reactive oxygen species (ROS) as well as total antioxidant capacity ( TAC ) within follicle fluid and body mass index ( BMI ) in patients with polycystic ovary syndrome (PCOS).Methods All patients enrolled in this study were infertile women receiving in vitro fertilization-embryo transfer (IVF-ET) treatment.55 PCOS patients were divided into over-weight group ( n =23 ) and non-over-weight group ( n =32 ).Another 55 age-matched non-PCOS women were also divided into control group ( n =30) and overweight group ( n =25 ).Plasma sex hormone,triglycerides,and total cholesterol were determined.On oocyte retrieval day after ovarian stimulation,ROS and TAC in follicular fluid were assayed.Results Subjects in over-weight and PCOS over-weight groups had higher triglycerides than those in control and PCOS non-over-weight groups [ ( 1.9 ±1.1,1.7 ± 0.9,1.0 ± 0.5,1.2 ± 0.7 ) mmol/L,respectively,all P＜0.05],so did total cholesterol [ ( 4.8 ± 1.2,5.2 ± 1.1,4.0 ± 0.6) mmol/L,respectively,all P＜0.05].In PCOS over-weight group,ROS and ROS/TAC within follicular fluid were ( 35.4 ± 6.7 ) RLU/S and 39.8 ± 22.0,both were higher than those in the other 3 groups ( all P＜0.05).TAC [ (0.8 ± 0.5 ) Mm] was lower in PCOS over-weight group than that among the other 3 groups( all P＜0.05 ).ROS/TAC was higher in PCOS non-over-weight group than that of control group ( 26.5 ± 14.5 vs 14.2 ± 12.5,P＜0.05 ).Univariate analysis showed that both ROS and ROS/TAC within follicular fluid in PCOS patients were positively correlated with BMI ( r =0.34 and r =0.32,both P＜0.05 ).Conclusion Abnormal oxidative stress exists in follicular fluid of PCOS patients,and the oxidative stress parameters show positive correlation with BMI.
