CAJ | 학술논문

目的探讨颈-脑动脉脉搏波传导速度(carotid-cerebral pulse wave velocity,ccPWV)的测量方法及其与传统测量方法肱踝脉搏波传导速度(brachial-ankle pulse wave velocity,baPWV)的相关性.方法 136名健康志愿者按年龄分为青年组(20～39岁)、中年组(40 ～ 59岁)和老年组(≥60岁),在检测baPWV的同时,采用经颅多普勒超声同步监测同侧颈总动脉和颈内动脉终末段,测量两者心动周期起跳点间的时间差以及两探头间的皮表距离,计算ccPWV.结果老年组收缩压、脉压和平均动脉压显著高于中年组和青年组.青年、中年和老年组ccPWV分别为(418±52) cm/s、(489±54)cm/s和(599±58) cm/s,老年组显著快于中年组(t=7.308,P＜0.001),中年组又显著快于青年组(t =6.758,P＜0.001).Pearson相关分析显示,ccPWV与年龄(r=0.847,P＜0.001)和baPWV(r=0.548,P＜0.001)呈显著性正相关.多重线性回归分析显示,ccPWV与年龄和舒张压均呈显著性正相关(偏相关系数分别为0.742和0.293,P分别＜0.001和＜0.010).结论 ccPWV是一种新型脑血管僵硬度测量方法,与传统测量方法具有良好的相关性.
목적 탐토경-뇌동맥맥박파전도속도(carotid-cerebral pulse wave velocity,ccPWV)적측량방법급기여전통측량방법굉과맥박파전도속도(brachial-ankle pulse wave velocity,baPWV)적상관성.방법 136명건강지원자안년령분위청년조(20～39세)、중년조(40 ～ 59세)화노년조(≥60세),재검측baPWV적동시,채용경로다보륵초성동보감측동측경총동맥화경내동맥종말단,측량량자심동주기기도점간적시간차이급량탐두간적피표거리,계산ccPWV.결과 노년조수축압、맥압화평균동맥압현저고우중년조화청년조.청년、중년화노년조ccPWV분별위(418±52) cm/s、(489±54)cm/s화(599±58) cm/s,노년조현저쾌우중년조(t=7.308,P＜0.001),중년조우현저쾌우청년조(t =6.758,P＜0.001).Pearson상관분석현시,ccPWV여년령(r=0.847,P＜0.001)화baPWV(r=0.548,P＜0.001)정현저성정상관.다중선성회귀분석현시,ccPWV여년령화서장압균정현저성정상관(편상관계수분별위0.742화0.293,P분별＜0.001화＜0.010).결론 ccPWV시일충신형뇌혈관강경도측량방법,여전통측량방법구유량호적상관성.
Objective To investigate the correlation between the measurement methods of carotidcerebral pulse wave velocity (ccPWV) and the traditional method of brachial-ankle pulse wave velocity (baPWV).Methods A total of 136 healthy volunteers were divided into a youth group (20-39 years),a middleaged group (40-59 years),and an elderly group (more than 60 years) according to their ages.While detecting baPWV,transcranial Doppler ultrasound was used to simultaneously monitor the ipsilateral common carotid artery and the terminal segment of internal carotid artery.The time differences of the beating points of their cardiac cycles and the distanceses of the skin surfaces between the 2 probes were measured and ccPWV was calculated.Results The systolic blood pressure,pulse pressure and mean arterial pressure in the elderly group were signifificantly higher than those in the middle-aged group and the young group.The ccPWVs in the youth,middle-aged and elderly groups were 418 ± 52 cm/s,489 ±54 cm/s,and 599 ± 58 cm/s,respectively.The elderly group was significantly faster than the middle-aged group (t =7.308,P ＜0.001),and the middle-aged group was significantly faster than the youth group (t=6.758,P＜0.001).A Pearson correlation analysis showed that ccPWV was significantly positively associated with the age (r=0.847,P＜0.001) and baPWV (r =0.548,P ＜0.001).The multiple linear regression analysis showed that ccPWV was significantly positively associated with the age and diastolic blood pressure (partial correlation coefficients were 0.742 and 0.293respectively,P ＜0.001 and ＜0.010 respectively).Conchlusions ccPWV is a new measurement method for cerebrovascular stiffneas,and it has a good correlation with the traditional measurement method.