CAJ | 학술논문

本文提出了流动注射-原子吸收光谱法间接测定西米替丁的新方法.基于西米替丁与Ag(Ⅰ)反应可以生成白色的沉淀,经流动注射在线过滤稀释,以原子吸收光谱法测定反应剩余银离子的量来间接测定西米替丁的量.在优化条件下西米替丁浓度在2～80 mg/L范围内与吸光度呈良好的线性关系,回收率为97.0%～104.3%.方法用于片剂西米替丁的测定,结果满意.
본문제출료류동주사-원자흡수광보법간접측정서미체정적신방법.기우서미체정여Ag(Ⅰ)반응가이생성백색적침정,경류동주사재선과려희석,이원자흡수광보법측정반응잉여은리자적량래간접측정서미체정적량.재우화조건하서미체정농도재2～80 mg/L범위내여흡광도정량호적선성관계,회수솔위97.0%～104.3%.방법용우편제서미체정적측정,결과만의.
A method for the indirect determination of cimetidine content in tablets by flow injection absorption spectrometry was proposed. It is based on the reaction of cimetidine with Ag+ in aqueous solution to form quantitatively white precipitate, and the content of residual Ag+ is determined by flow injection atomic absorption spectrometry with on-line dilution, therefore the cimetidine content can be determined indirectly. Under the optimum conditions, a standard calibration curve was obtained with a linear range of 2～80 mg/L with correlation coefficient of R=0.9982. The reliability of the procedure was established by repeating experiments with recoveries ranging from 97.0%～104.3%. The method has been applied to the determination of cimetidine in tablets with satisfactory result.