CAJ | 학술논문

将新鲜蜂王浆经过180目滤网过滤,滤液再逐步经过0.50 μm、0.10μm和0.05 μm的无机陶瓷膜过滤,分别得到了5种蜂王浆活性组分,测定新鲜蜂王浆及各活性组分的癸烯酸含量.将88只荷瘤小鼠随机分为环磷酰胺组(40mg/kg)、模型对照组、蜂王浆及各组分实验组,连续灌胃4周.观察小鼠一般状况,测定抑瘤率和脏体系数,以探讨蜂王浆各组分对荷S180肿瘤小鼠的免疫效果.结果表明,除新鲜王浆先后经过180目滤网,0.50μm和0.10μm无机陶瓷膜过滤的组分外,其他各蜂王浆组分与对照组比较对降低瘤体重量差异不显著,其中E组抑瘤率最高达45.52%.说明蜂王浆不同活性组分对荷S180肿瘤小鼠抗癌作用有差异.
장신선봉왕장경과180목려망과려,려액재축보경과0.50 μm、0.10μm화0.05 μm적무궤도자막과려,분별득도료5충봉왕장활성조분,측정신선봉왕장급각활성조분적계희산함량.장88지하류소서수궤분위배린선알조(40mg/kg)、모형대조조、봉왕장급각조분실험조,련속관위4주.관찰소서일반상황,측정억류솔화장체계수,이탐토봉왕장각조분대하S180종류소서적면역효과.결과표명,제신선왕장선후경과180목려망,0.50μm화0.10μm무궤도자막과려적조분외,기타각봉왕장조분여대조조비교대강저류체중량차이불현저,기중E조억류솔최고체45.52%.설명봉왕장불동활성조분대하S180종류소서항암작용유차이.
[Objective] To investigate the effect of active components of royal jelly on S180 sarcoma growth of mice. [Methods] The fresh royal jelly through a filter with 180 meshes was filtered by inorganic membranes with size of 0.50μm、0.10μm and 0.05μm、5 groups of different components of royal jelly were got,then the content of 10-HDA were determined. 88 tumor-bearing mice were randomized into cyclophosphamide (CTX) group,negative control and royal jelly groups,fed for 4 weeks continuously. The general condition of mice was observed,the inhibitory rate of tumor growth and organic index were determined and analyzed. [Results] The tumor growth was significantly inhibited and tumor weight was reduced in experimental groups except group D,highest to 45.52% in comparison with the tumor control group. [Conclusion] Inhibitory effect of different active components of royal jelly on S180 sarcoma growth of mice was different.