中华妇幼临床医学杂志（电子版）
中華婦幼臨床醫學雜誌（電子版）
중화부유림상의학잡지（전자판）
CHINESE JOURNAL OF OBSTETRICS & GYNECOLOGY AND PEDIATRICS(ELECTRONIC VERSION)
2012年
4期
361-363
,共3页
人乳头瘤病毒%感染率%亚型分布%相关因素
人乳頭瘤病毒%感染率%亞型分佈%相關因素
인유두류병독%감염솔%아형분포%상관인소
human papillomavirus%infection rate%genotypes distribution%related factors
目的 探讨人乳头瘤病毒(HPV)感染现状及感染相关因素,为预防和控制HPV感染提供理论依据.方法 选取2009年1月至2010年12月于本院妇科门诊就诊的508例自愿接受宫颈HPV检查者为研究对象,取其宫颈脱落细胞标本,采用快速导流杂交技术HPV DNA检测法进行HPV基因型分型.并采用多因素Logistic回归模型分析,探讨HPV感染的相关因素,包括年龄、文化程度、初次性生活年龄、流产次数、性伴侣数、配偶伴侣数、吸烟史及避孕方式等(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,征得受试对象的知情同意).结果 本组508例受试者HPV总感染率为22.05％(112/508),其中高危型HPV(HR-HPV)感染率为18.90％ (95/508),低危型HPV(LR-HPV)感染率为2.17％(11/508),中国人常见感染基因型为1.18％％(6/508).508例受试者中,感染率最高的5种HPV基因型分别为HPV-16(7.68％)-52(4.72％),-58(3.74％),-18(3.15％),-31(2.36％).影响HPV感染的相关因素为:初次性生活年龄、性伴侣数、配偶性伴侣数、流产次数及吸烟史(x2=105.539,5.092,37.158,5.076,13.824;P＜0.05),进一步行多因素非条件Logistic回归分析显示,初次性生活年龄(OR=13.036)、性伴侣数(OR=5.860)、配偶性伴侣数(OR=2.120)、吸烟史(OR=2.054)为影响HPV感染的独立危险因素(P＜0.05).结论 不良的生活习惯及性行为是女性HPV感染的高危因素,改变不良生活习惯及性行为是预防HPV感染的有效手段.
目的 探討人乳頭瘤病毒(HPV)感染現狀及感染相關因素,為預防和控製HPV感染提供理論依據.方法 選取2009年1月至2010年12月于本院婦科門診就診的508例自願接受宮頸HPV檢查者為研究對象,取其宮頸脫落細胞標本,採用快速導流雜交技術HPV DNA檢測法進行HPV基因型分型.併採用多因素Logistic迴歸模型分析,探討HPV感染的相關因素,包括年齡、文化程度、初次性生活年齡、流產次數、性伴侶數、配偶伴侶數、吸煙史及避孕方式等(本研究遵循的程序符閤本院人體試驗委員會所製定的倫理學標準,得到該委員會批準,徵得受試對象的知情同意).結果 本組508例受試者HPV總感染率為22.05％(112/508),其中高危型HPV(HR-HPV)感染率為18.90％ (95/508),低危型HPV(LR-HPV)感染率為2.17％(11/508),中國人常見感染基因型為1.18％％(6/508).508例受試者中,感染率最高的5種HPV基因型分彆為HPV-16(7.68％)-52(4.72％),-58(3.74％),-18(3.15％),-31(2.36％).影響HPV感染的相關因素為:初次性生活年齡、性伴侶數、配偶性伴侶數、流產次數及吸煙史(x2=105.539,5.092,37.158,5.076,13.824;P＜0.05),進一步行多因素非條件Logistic迴歸分析顯示,初次性生活年齡(OR=13.036)、性伴侶數(OR=5.860)、配偶性伴侶數(OR=2.120)、吸煙史(OR=2.054)為影響HPV感染的獨立危險因素(P＜0.05).結論 不良的生活習慣及性行為是女性HPV感染的高危因素,改變不良生活習慣及性行為是預防HPV感染的有效手段.
목적 탐토인유두류병독(HPV)감염현상급감염상관인소,위예방화공제HPV감염제공이론의거.방법 선취2009년1월지2010년12월우본원부과문진취진적508례자원접수궁경HPV검사자위연구대상,취기궁경탈락세포표본,채용쾌속도류잡교기술HPV DNA검측법진행HPV기인형분형.병채용다인소Logistic회귀모형분석,탐토HPV감염적상관인소,포괄년령、문화정도、초차성생활년령、유산차수、성반려수、배우반려수、흡연사급피잉방식등(본연구준순적정서부합본원인체시험위원회소제정적윤리학표준,득도해위원회비준,정득수시대상적지정동의).결과 본조508례수시자HPV총감염솔위22.05％(112/508),기중고위형HPV(HR-HPV)감염솔위18.90％ (95/508),저위형HPV(LR-HPV)감염솔위2.17％(11/508),중국인상견감염기인형위1.18％％(6/508).508례수시자중,감염솔최고적5충HPV기인형분별위HPV-16(7.68％)-52(4.72％),-58(3.74％),-18(3.15％),-31(2.36％).영향HPV감염적상관인소위:초차성생활년령、성반려수、배우성반려수、유산차수급흡연사(x2=105.539,5.092,37.158,5.076,13.824;P＜0.05),진일보행다인소비조건Logistic회귀분석현시,초차성생활년령(OR=13.036)、성반려수(OR=5.860)、배우성반려수(OR=2.120)、흡연사(OR=2.054)위영향HPV감염적독립위험인소(P＜0.05).결론 불량적생활습관급성행위시녀성HPV감염적고위인소,개변불량생활습관급성행위시예방HPV감염적유효수단.
Objective To investigate prevalence,genotypes distribution and related infection factors of human papillomavirus (HPV) in order to provide scientific evidence for the prevention and control of HPV infection.Methods From January 2009 to December 2010,a total of 508 women who received cervical HPV testing in Second Affiliated Hospital of Qingdao University Medical College were included into this study.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Second Affiliated Hospital of Qingdao University Medical College.After obtaining specimens of cervical cytology,rapid flow through hybridization technique (namely Hybribio flow-through hybridization) was used to detect HPV genotypes simultaneously.Multiple factors non-conditional logistic regression analytic method was used to discuss the relationship between HPV infection and related factors (age,educational level,initial age for sex,number of pregnancy termination,number of sexual partners,number of spouse's sexual partners,smoking history and contraception measures).Results Among 508 women received HPV infection test,the total HPV infection rate was 22.05％ (112/508),including the high risk HPV (HR-HPV) subtypes infection rate was 18.90％ (95/508),the low-risk HPV (LR-HPV) subtypes infection rate was 2.17％(11/508),the most common type of Chinese was 1.18％ (6/508).The top five high-risk subtypes were HPV-16(7.68％),-52 (4.72％),-58(3.74％),-18 (3.15％),-31 (2.36％). The relative factors of HPV infection in 508 women were initial age for sex,number of sexual partners,number of spouse's sexual partners,number of pregnancy termination and smoking history (x2 =105.539,5.092,37.158,5.076,13.824,respectively,P＜0.05).Multiple factor non-conditional Logistic regression model analysis showed that the independent factors were initial age for sex (OR=13.036),number of sexual partners (OR=5.860),number of spouse' s sexual partners (OR =2.120),and smoking history (OR =2.054).Conclusions The independent risk factors for HPV infection in women are bad living habits and bad sexual behavior.Changing bad living habits and bad sexual behavior are effective ways to prevent HPV infection.
