中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
34期
23-26
,共4页
营养支持%呼吸,人工%营养状况
營養支持%呼吸,人工%營養狀況
영양지지%호흡,인공%영양상황
Nutritional support%Respiration,artificial%Nutritional status
目的 评估营养支持联合重组人生长激素(rhGH)在机械通气患者中应用的效果.方法 ICU住院患者中需机械通气患者共150例,试验组(营养支持联合rhGH)80例,对照组(单纯营养支持)70例,热量按Harris-Benedict公式换算供给,供氮量0.25 g/(kg·d),试验组予rhGH 0.1U/(kg·d)皮下注射7 d,对比研究两组在各营养状况指标、免疫功能指标及临床指标等方面的不同影响.结果 治疗后7 d,试验组比对照组在各营养状况指标和免疫功能指标方面有明显改善,一次脱机成功率高.治疗后7d,试验组患者转铁蛋白(3.0±0.6)g/L、前白蛋白(226.46±27.02)mg/L、CD3(53.8±3.3)%、CD4(0.41±0.14)%、NK(16.1±2.1)%,均较对照组患者的(1.9±0.4)g/L、(188.68±17.27)mg/L、(47.4±4.1)%、(0.25±0.05)%和(10.9±3.0)%明显升高,差异有统计学意义(P＜0.01).结论 营养支持联合rhGH比单纯营养支持对机械通气患者营养状态的改善具有更佳的疗效,同时对机体的免疫功能也有一定的调理作用.
目的 評估營養支持聯閤重組人生長激素(rhGH)在機械通氣患者中應用的效果.方法 ICU住院患者中需機械通氣患者共150例,試驗組(營養支持聯閤rhGH)80例,對照組(單純營養支持)70例,熱量按Harris-Benedict公式換算供給,供氮量0.25 g/(kg·d),試驗組予rhGH 0.1U/(kg·d)皮下註射7 d,對比研究兩組在各營養狀況指標、免疫功能指標及臨床指標等方麵的不同影響.結果 治療後7 d,試驗組比對照組在各營養狀況指標和免疫功能指標方麵有明顯改善,一次脫機成功率高.治療後7d,試驗組患者轉鐵蛋白(3.0±0.6)g/L、前白蛋白(226.46±27.02)mg/L、CD3(53.8±3.3)%、CD4(0.41±0.14)%、NK(16.1±2.1)%,均較對照組患者的(1.9±0.4)g/L、(188.68±17.27)mg/L、(47.4±4.1)%、(0.25±0.05)%和(10.9±3.0)%明顯升高,差異有統計學意義(P＜0.01).結論 營養支持聯閤rhGH比單純營養支持對機械通氣患者營養狀態的改善具有更佳的療效,同時對機體的免疫功能也有一定的調理作用.
목적 평고영양지지연합중조인생장격소(rhGH)재궤계통기환자중응용적효과.방법 ICU주원환자중수궤계통기환자공150례,시험조(영양지지연합rhGH)80례,대조조(단순영양지지)70례,열량안Harris-Benedict공식환산공급,공담량0.25 g/(kg·d),시험조여rhGH 0.1U/(kg·d)피하주사7 d,대비연구량조재각영양상황지표、면역공능지표급림상지표등방면적불동영향.결과 치료후7 d,시험조비대조조재각영양상황지표화면역공능지표방면유명현개선,일차탈궤성공솔고.치료후7d,시험조환자전철단백(3.0±0.6)g/L、전백단백(226.46±27.02)mg/L、CD3(53.8±3.3)%、CD4(0.41±0.14)%、NK(16.1±2.1)%,균교대조조환자적(1.9±0.4)g/L、(188.68±17.27)mg/L、(47.4±4.1)%、(0.25±0.05)%화(10.9±3.0)%명현승고,차이유통계학의의(P＜0.01).결론 영양지지연합rhGH비단순영양지지대궤계통기환자영양상태적개선구유경가적료효,동시대궤체적면역공능야유일정적조리작용.
Objective To evaluate the effects of nutritional support combined with human growth hormone recombinant (rhGH) in patients with mechanical ventilation. Methods One hundred and fifty cases in ICU were randomized into test group (nutritional support combined with rhGH, 80 cases) and control group (nutritional support,70 cases). Both groups received calories according to Harris-Benedict formula [N, 0.25 g/(kg· d)]. In addition, the test group received subcutaneous injections of rhGH at a dose of 0. 1 U/ (kg· d) for 7 days. The different effects on nutritional status indexes, immunological function indexes and clinical indexes were compared. Results Compared with the control group,there were significant improvement in nutritional status indexes and immunological function indexes after the treatment of 7 days. The success rate of once weaning was higher in test group than that in control group. There were significant differences in the level of transferrin, prealbumin, CD3, CD4, NK between two groups [(3.0 ± 0.6)g/L vs. ( 1.9 ± 0.4) g/L, (226.46 ± 27.02 ) mg/L vs. ( 188.68 ± 17.27 ) mg/L, (53.8 ± 3.3 ) % vs. (47.4 ±4.1 ) %, ( 0.41 ± 0.14 ) % vs. (0.25 ± 0.05 ) %, ( 16.1 ± 2.1 ) % vs. ( 10.9 ± 3.0 ) %] ( P ＜ 0.01 ). Conclusion rhGH combined with nutritional support has more effects on improving nutritional status compared with those of single nutritional support. It has significant adjustment effect on immunological function in patients with mechanical ventilation.
