CAJ | 학술논문

目的观察三氧化二砷(ATO)联合全反式维A酸(ATRA)治疗急性早幼粒细胞白血病(APL)的疗效与安全性.方法 83例初治APL患者按随机数字表法分为两组,观察组48例采用ATO联合ATRA诱导缓解治疗,对照组35例采用ATRA联合化疗诱导治疗,比较两组的疗效及不良反应发生情况.结果观察组有效率和早期病死率分别为100.0％(48/48)和O,对照组分别为97.1％(34/35)和2.9％( 1/35),两组比较差异无统计学意义(P＞0.05).观察组骨髓抑制、感染、肝肾损害、心脏毒性和消化道症状发生率分别为8.3％(4/48)、10.4％(5/48)、12.5％ (6/48)、6.2％(3/48)和18.8％(9/48),而对照组分别为97.1％(34/35)、65.7％(23/35)、45.7％(16/35)、37.1％(13/35)和100.0％(35/35),两组比较差异有统计学意义(P＜0.05).结论 ATO联合ATRA治疗APL,疗效显著,不良反应少,值得临床推广应用.
목적 관찰삼양화이신(ATO)연합전반식유A산(ATRA)치료급성조유립세포백혈병(APL)적료효여안전성.방법 83례초치APL환자안수궤수자표법분위량조,관찰조48례채용ATO연합ATRA유도완해치료,대조조35례채용ATRA연합화료유도치료,비교량조적료효급불량반응발생정황.결과 관찰조유효솔화조기병사솔분별위100.0％(48/48)화O,대조조분별위97.1％(34/35)화2.9％( 1/35),량조비교차이무통계학의의(P＞0.05).관찰조골수억제、감염、간신손해、심장독성화소화도증상발생솔분별위8.3％(4/48)、10.4％(5/48)、12.5％ (6/48)、6.2％(3/48)화18.8％(9/48),이대조조분별위97.1％(34/35)、65.7％(23/35)、45.7％(16/35)、37.1％(13/35)화100.0％(35/35),량조비교차이유통계학의의(P＜0.05).결론 ATO연합ATRA치료APL,료효현저,불량반응소,치득림상추엄응용.
Objective To observe the effect and safety of arsenic trioxide (ATO) combined with all-trans retinoic acid (ATRA) in treating patients with acute promyelocytic leukemia (APL).Methods Eighty-three cases with APL treated for the first time were divided into two groups by random digits table method:observation group with 48 cases was received combination induction treatment of ATO and ATRA,control group with 35 cases was treated with combination induction treatment of ATRA and chemotherapy.The clinical effect and adverse reaction between two groups were compared.Results The effective rate and early death rate were 100.0％( 48/48 ) and 0 in observation group,97.1％(34/35 ) and 2.9％( 1/35 ) in control group,which had no significant difference between two groups (P ＞ 0.05 ).The incidences of bone marrow suppression,infection,liver and kidney damage,cardiac toxicity and gastrointestinal symptoms were 8.3％ (4/48),10.4％ (5/48),12.5％ (6/48),6.2％ (3/48) and 18.8％ (9/48) in observation group,while 97.1％(34/35),65.7％(23/35),45.7％(16/35),37.1％(13/35) and 100.0％(35/35) in control group,which had significant differences between two groups (P ＜ 0.05).Conclusion Combination treatment of ATO and ATRA in APL has an obvious effect and few adverse reaction,which can be applied in clinic.