CAJ | 학술논문

目的比较玻璃酸钠与玻璃酸钠联合曲安奈德膝关节腔内注射治疗膝关节骨性关节炎(0A)的疗效.方法选取2010年3月至2011年3月接受膝关节腔内注射治疗的82例膝关节OA患者,以掷硬币法随机分为两组:单纯接受玻璃酸钠腔内注射42例(玻璃酸钠组),玻璃酸钠联合曲安奈德腔内注射40例(联合组).两组均每周注射1次,共5次.疗效评价包括疼痛视觉模拟量表(VAS)测量值以及安全性评估.结果联合组在注射后1周上下楼梯时VAS测量值为(22.6±6.1)mm,较玻璃酸钠组的(63.9±5.8) mm显著降低,差异有统计学意义(P＜0.05).联合组和玻璃酸钠组在疗程结束后3个月和6个月上下楼梯时VAS测量值比较差异无统计学意义[(42.2±6.6) mm比(41.1±5.3) mm,(48.5±5.5)mm比(49.3±6.2) mm](P＞ 0.05).两组治疗后膝关节功能皆优于治疗前,不良反应少见且轻微.结论玻璃酸钠与玻璃酸钠联合曲安奈德腔内注射都可以作为治疗膝关节OA的安全、有效的方法.玻璃酸钠联合应用曲安奈德可以提高治疗初期的疗效.
목적 비교파리산납여파리산납연합곡안내덕슬관절강내주사치료슬관절골성관절염(0A)적료효.방법 선취2010년3월지2011년3월접수슬관절강내주사치료적82례슬관절OA환자,이척경폐법수궤분위량조:단순접수파리산납강내주사42례(파리산납조),파리산납연합곡안내덕강내주사40례(연합조).량조균매주주사1차,공5차.료효평개포괄동통시각모의량표(VAS)측량치이급안전성평고.결과 연합조재주사후1주상하루제시VAS측량치위(22.6±6.1)mm,교파리산납조적(63.9±5.8) mm현저강저,차이유통계학의의(P＜0.05).연합조화파리산납조재료정결속후3개월화6개월상하루제시VAS측량치비교차이무통계학의의[(42.2±6.6) mm비(41.1±5.3) mm,(48.5±5.5)mm비(49.3±6.2) mm](P＞ 0.05).량조치료후슬관절공능개우우치료전,불량반응소견차경미.결론 파리산납여파리산납연합곡안내덕강내주사도가이작위치료슬관절OA적안전、유효적방법.파리산납연합응용곡안내덕가이제고치료초기적료효.
Objective To compare the therapeutic effect of intraarticular injection with sodium hyaluronate (SH) and SH combined with triamcinolone acetonide for osteoarthritis (OA) of knee joint.Methods Eighty-two patients with OA of knee joint were divided into two groups by toss a coin from March 2010 to March 2011.Forty-two patients simplely accepted SH injection (SH group),40 patients accepted SH combined with triamcinolone acetonide (combination group).Intraarticular injection was taken once a week,a total of 5 times.Efficacy measurements included visual analog scale (VAS) for pain and safety.Results After treatment for 1 week,the measured value of VAS for up and down stairs in combination group was significantly lower than that in SH group [ (22.6 ± 6.1 ) mm vs.(63.9 ± 5.8 ) mm] (P ＜ 0.05 ).After treatment for 3,6 months,the measured value of VAS for up and down stairs in two groups had no significant difference [ (42.2 ± 6.6) mm vs.(41.1 ± 5.3) mm,(48.5 ± 5.5) mm vs.(49.3 ± 6.2) mm] (P ＞ 0.05).Function of the knee joint after treatment was better than before treatment in two groups.Adverse effects were minimal. Conclusions Intraarticular injection of SH and SH combined with triamcinolone acetonide OA of knee joint is a safe and effective method.SH combined with triamcinolone acetonide can improve the efficacy in early period.