CAJ | 학술논문

目的研究行为、遗传因素与2型糖尿病(type 2 diabetes mellitus,T2DM)的关系,为T2DM患者制订综合预防和干预措施提供科学依据.方法采用病例对照研究方法对山东省梁山县T2DM患者(152例)及对照组(120例)核心家系进行调查,收集病例及对照组成员生活行为及一级亲属家族信息,应用单因素和多因素非条件logistic回归分析研究各因素在疾病发生中的作用,并采用Falconer法估算遗传度.结果多因素非条件logistic回归分析表明糖尿病家族史、高脂饮食、高糖饮食、体育锻炼、多食绿色蔬菜及腰臀比(WHR)等因素与T2DM之间关系有统计学意义,病例组一级亲属累积发病率为6.60%,对照组一级亲属累积发病率为1.18%,二者差异有显著性(x2=44.839,P＜0.01),152个家系一级亲属T2DM遗传度为57.4%.结论 T2DM是遗传和行为危险因素共同作用的结果.
목적 연구행위、유전인소여2형당뇨병(type 2 diabetes mellitus,T2DM)적관계,위T2DM환자제정종합예방화간예조시제공과학의거.방법 채용병례대조연구방법대산동성량산현T2DM환자(152례)급대조조(120례)핵심가계진행조사,수집병례급대조조성원생활행위급일급친속가족신식,응용단인소화다인소비조건logistic회귀분석연구각인소재질병발생중적작용,병채용Falconer법고산유전도.결과 다인소비조건logistic회귀분석표명당뇨병가족사、고지음식、고당음식、체육단련、다식록색소채급요둔비(WHR)등인소여T2DM지간관계유통계학의의,병례조일급친속루적발병솔위6.60%,대조조일급친속루적발병솔위1.18%,이자차이유현저성(x2=44.839,P＜0.01),152개가계일급친속T2DM유전도위57.4%.결론 T2DM시유전화행위위험인소공동작용적결과.
Objective To study the relationship between behavioral,genetic factors and type 2 diabetes mellitus,and provide rational evidence for prevention and intervention of type 2 diabetes mellitus.Methods Case control study is adopted in the research,152 cases with type 2 diabetes mellitus and 120 controls were brought into the study,collecting information of their life styles and behavior,tracing information of their first degree relatives;single and multi-factor logistic regression are applied to analyze the effect of the studying factors on type 2 diabetes mellitus.Falconer formula is adopted to estimate heritability.Results According to multi-factor logistic regression,the factors associated with type 2 diabetes mellitus include:the family history of diabetes mellitus,absorbing too much fat,enjoying sweetmeats,take exercises,eating green flesh vegetables and waist haunch ratio(WHR)et al.The cumulative incidence rate of first degree relatives in eases is 7.55%,which is higher than that of controls (0.73%),the difference between the two is distinctly(x2=66.07,P＜0.01).By Falconer formula,the heritabilitv of type 2 diabetes mellitus is 72.2%.which indicate that heredity account for a big proportion in the occurrence of type 2 diabetes mellitus.Conclusion Type 2 diabetes mellitus is caused by the combining effects of genetic and behavior risky factors.