国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2012年
2期
86-90
,共5页
MDM4%MDM2%p53%癌基因%应激%肿瘤%化疗耐药
MDM4%MDM2%p53%癌基因%應激%腫瘤%化療耐藥
MDM4%MDM2%p53%암기인%응격%종류%화료내약
MDM4%MDM2%p53%Oncogene%Stress%Tumor%Chemoresistance
MDM4( murine double minute 4,MDMX,HDMX)是p53上游重要的调控因子.其结构与MDM2相近,但功能上比较复杂且有争议,一方面与MDM2相似,具有致癌基因活性.其高表达会导致抑癌基因p53失活而诱发肿瘤,另外一方面可激活p53,促进细胞凋亡.MDM4在不同外界应激下,有不同的调控途径.鉴于MDM4的重要性,此文将从该基因的结构、功能、与肿瘤关系、研究方向等方面系统总结目前对MDM4的认识及研究进展.
MDM4( murine double minute 4,MDMX,HDMX)是p53上遊重要的調控因子.其結構與MDM2相近,但功能上比較複雜且有爭議,一方麵與MDM2相似,具有緻癌基因活性.其高錶達會導緻抑癌基因p53失活而誘髮腫瘤,另外一方麵可激活p53,促進細胞凋亡.MDM4在不同外界應激下,有不同的調控途徑.鑒于MDM4的重要性,此文將從該基因的結構、功能、與腫瘤關繫、研究方嚮等方麵繫統總結目前對MDM4的認識及研究進展.
MDM4( murine double minute 4,MDMX,HDMX)시p53상유중요적조공인자.기결구여MDM2상근,단공능상비교복잡차유쟁의,일방면여MDM2상사,구유치암기인활성.기고표체회도치억암기인p53실활이유발종류,령외일방면가격활p53,촉진세포조망.MDM4재불동외계응격하,유불동적조공도경.감우MDM4적중요성,차문장종해기인적결구、공능、여종류관계、연구방향등방면계통총결목전대MDM4적인식급연구진전.
As a MDM2-structurally related protein,MDM4 (MDMX or HDMX) is a critical regulator of the p53 tumor suppressor.Its function is not simple,and it has shows as double-functions.Firstly,its over- expression of has been shown to enhances degradation and inactivation of the tumor suppressor p53.Secondly,it also can active p53,and thus promote cell apoptosis.This protein plays different roles in different stresses.Considering the critical role of MDM4,this review summarizes its structure and function,its relationship with tumorogenesis,and current progress of this protein.
