中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
5期
471-474
,共4页
张静%赵洛沙%高敏%杨帆%杜江川%李阳
張靜%趙洛沙%高敏%楊帆%杜江川%李暘
장정%조락사%고민%양범%두강천%리양
原发性高血压%脂蛋白(a)%冠心病%危险因素
原髮性高血壓%脂蛋白(a)%冠心病%危險因素
원발성고혈압%지단백(a)%관심병%위험인소
Essential hypertension%Lipoprotein(a)%Coronary heart disease%Risk factor
目的 探讨原发性高血压(EH)合并冠心病患者血清脂蛋白(a)[Lp(a)]水平的变化及其临床意义.方法 选择老年EH患者159例,根据冠状动脉造影结果分为单纯EH组73例和合并冠心病组86例,检测其空腹血糖、肌酐、总胆固醇、甘油三酯、LP(a)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),计算体重指数.结果 与单纯EH组相比,Lp(a)水平在EH合并冠心病组明显增高[(0.34±0.12)、(0.48±0.18)mmol/L,t=-11.367,P＜0.05],在EH合并冠心病组中随冠状动脉病变程度的加重Lp(a)水平呈增高趋势[单支、双支、多支及弥漫病变组分别为(0.34±0.14)、(0.46±0.15)、(0.66±0.12)mmol/L,F=31.842,P=0.012].结论 EH患者Lp(a)水平与冠心病的发生及其严重程度相关.Lp(a)作为冠心病的危险因素,可以预测冠状动脉病变的严重程度.
目的 探討原髮性高血壓(EH)閤併冠心病患者血清脂蛋白(a)[Lp(a)]水平的變化及其臨床意義.方法 選擇老年EH患者159例,根據冠狀動脈造影結果分為單純EH組73例和閤併冠心病組86例,檢測其空腹血糖、肌酐、總膽固醇、甘油三酯、LP(a)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C),計算體重指數.結果 與單純EH組相比,Lp(a)水平在EH閤併冠心病組明顯增高[(0.34±0.12)、(0.48±0.18)mmol/L,t=-11.367,P＜0.05],在EH閤併冠心病組中隨冠狀動脈病變程度的加重Lp(a)水平呈增高趨勢[單支、雙支、多支及瀰漫病變組分彆為(0.34±0.14)、(0.46±0.15)、(0.66±0.12)mmol/L,F=31.842,P=0.012].結論 EH患者Lp(a)水平與冠心病的髮生及其嚴重程度相關.Lp(a)作為冠心病的危險因素,可以預測冠狀動脈病變的嚴重程度.
목적 탐토원발성고혈압(EH)합병관심병환자혈청지단백(a)[Lp(a)]수평적변화급기림상의의.방법 선택노년EH환자159례,근거관상동맥조영결과분위단순EH조73례화합병관심병조86례,검측기공복혈당、기항、총담고순、감유삼지、LP(a)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C),계산체중지수.결과 여단순EH조상비,Lp(a)수평재EH합병관심병조명현증고[(0.34±0.12)、(0.48±0.18)mmol/L,t=-11.367,P＜0.05],재EH합병관심병조중수관상동맥병변정도적가중Lp(a)수평정증고추세[단지、쌍지、다지급미만병변조분별위(0.34±0.14)、(0.46±0.15)、(0.66±0.12)mmol/L,F=31.842,P=0.012].결론 EH환자Lp(a)수평여관심병적발생급기엄중정도상관.Lp(a)작위관심병적위험인소,가이예측관상동맥병변적엄중정도.
Objective To study the changes of lipoprotein(a)[LP(a)] in patients with essential hypertension(EH) and coronary heart disease(CHD).Methods One hundred and fifty-nine EH older patients were recruited in the study.Eighty-six elderly patients were diagnosed as EH combined with CHD,and 73 patients were diagnosed as simple EH.All patients were tested for the fasting blood glucose(FBG),creatinine(Cr),total cholesterol(TC),triglyceride(TG),HDL-C,LDL-C,LP(a),and the body mass index(BMI) was calculated.Results Plasma Lp(a) increased(0.48±0.18)mmol/L in the EH combined with CHD patients,which were significantly higher than the increasing of(0.34±0.12) mmol/L in the simple EH patients(t=-11.367,P＜0.05).The level of plasma Lp(a) increased with the severity of the stenosis of the coronary artery(Lp(a):(0.37±0.14) mmol/L in single arterial branch stenoses,(0.46±0.15)mmol/L in double arterial branch stenoses,(0.66±0.12)mmol/L in triangle arterial branch stenoses,F=31.842,P=0.012).Conclusion The Lp(a) concentration in patients with EH are correlated with the occurrence and severity of coronary heart disease.As a risk of coronary heart disease,Lp(a) can predict the severity of coronary artery stenosis.
