中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2011年
7期
741-743
,共3页
宋蕊%冯亮%李兴旺%徐艳丽%卢联合%蒋荣猛%陈志海
宋蕊%馮亮%李興旺%徐豔麗%盧聯閤%蔣榮猛%陳誌海
송예%풍량%리흥왕%서염려%로연합%장영맹%진지해
鼠神经生长因子%手足口病%中枢神经系统
鼠神經生長因子%手足口病%中樞神經繫統
서신경생장인자%수족구병%중추신경계통
Mouse nervous growth factor,Hand-foot-and-mouth disease%Central nervous system
目的 探讨鼠神经生长因子在手足口病合并中枢神经系统损害患者治疗中的应用.方法 收集北京地坛医院自2008年5月至2010年9月收治的手足口病合并中枢神经系统损害并使用鼠神经生长因子治疗的48例患者的临床资料,采用回顾性分析方法总结其特点.结果 5岁以下尤其是1～3岁儿童是手足口病合并中枢神经系统损害高危人群.患者急性弛缓性麻痹症状出现时间平均在病程第(7.1±3.6)天,肌力恢复平均在第(17.5±6.0)天;呕吐症状出现和消失的平均时间分别为病程第(4.29±3.10)天和第(5.74±2.90)天;易惊症状出现和消失的平均时间为病程第(2.67±1.76)天和第(7.80±2.76)天.实验室检查显示患者白细胞及CK值均有不同程度升高,脑脊液压力、蛋白表达不同程度升高MRI提示延髓部位最常受累,其次为脑干等部位.结论 鼠神经生长因子应用于手足口病合并中枢神经系统损害患者时有助于改善患者的神经系统症状及预后.
目的 探討鼠神經生長因子在手足口病閤併中樞神經繫統損害患者治療中的應用.方法 收集北京地罈醫院自2008年5月至2010年9月收治的手足口病閤併中樞神經繫統損害併使用鼠神經生長因子治療的48例患者的臨床資料,採用迴顧性分析方法總結其特點.結果 5歲以下尤其是1～3歲兒童是手足口病閤併中樞神經繫統損害高危人群.患者急性弛緩性痳痺癥狀齣現時間平均在病程第(7.1±3.6)天,肌力恢複平均在第(17.5±6.0)天;嘔吐癥狀齣現和消失的平均時間分彆為病程第(4.29±3.10)天和第(5.74±2.90)天;易驚癥狀齣現和消失的平均時間為病程第(2.67±1.76)天和第(7.80±2.76)天.實驗室檢查顯示患者白細胞及CK值均有不同程度升高,腦脊液壓力、蛋白錶達不同程度升高MRI提示延髓部位最常受纍,其次為腦榦等部位.結論 鼠神經生長因子應用于手足口病閤併中樞神經繫統損害患者時有助于改善患者的神經繫統癥狀及預後.
목적 탐토서신경생장인자재수족구병합병중추신경계통손해환자치료중적응용.방법 수집북경지단의원자2008년5월지2010년9월수치적수족구병합병중추신경계통손해병사용서신경생장인자치료적48례환자적림상자료,채용회고성분석방법총결기특점.결과 5세이하우기시1～3세인동시수족구병합병중추신경계통손해고위인군.환자급성이완성마비증상출현시간평균재병정제(7.1±3.6)천,기력회복평균재제(17.5±6.0)천;구토증상출현화소실적평균시간분별위병정제(4.29±3.10)천화제(5.74±2.90)천;역량증상출현화소실적평균시간위병정제(2.67±1.76)천화제(7.80±2.76)천.실험실검사현시환자백세포급CK치균유불동정도승고,뇌척액압력、단백표체불동정도승고MRI제시연수부위최상수루,기차위뇌간등부위.결론 서신경생장인자응용우수족구병합병중추신경계통손해환자시유조우개선환자적신경계통증상급예후.
Objective To investigate the application of mouse nervous growth factor (mNGF) on patients with hand-foot-and-mouth disease (HFMD) combined with central nervous system damage. Methods Clinical data of 48 patients with HFMD combined with central nervous system damage, admitted to our hospital and received treatment of mNGF from May 2008 to September 2010, were analyzed retrospectively. Results Children under 5 years old, especially between 1-3 years old, were the high-risk group of having HFMD combined with central nervous system damage. The average time of appearing of acute flaccid paralysis (AFP) and recovering of muscle strength were (7.1±3.6) d and (17.5±6.0) d, respectively. A total of 31 patients (64.58%) appeared vomiting, with its average times of appearance and disappearance as (4.29±3.10) d and (5.74±2.90) d, respectively. A total of 33 patients (68.75%) tended to appear panic symptoms, which appeared on (2.67±1.76) d and disappeared on (7.80± 2.76) d averagely. Laboratory test showed number of white blood cells and CK values were elevated of certain degree, and cerebrospinal fluid pressure and protein expression level were increased to varying degrees. MRI showed that bulbus medulla was the most likely to be involved, followed by brain stem and other parts. Conclusion Application of mNGF on patients with HFMD combined with central system damage may help to improve the neurologic symptoms and prognosis.
