CAJ | 학술논문

目的：观察抗高热I号合剂(AFMI)对发热家兔脑脊液前列腺素E(PGE)、环磷酸腺苷(cAMP)含量的影响。方法：用肺炎双球菌感染家兔，造成发热模型，提前应用AFMI合剂及以两种不同剂量于家兔体温达到高峰时应用，观测家兔脑脊液PGE、cAMP含量的变化并进行比较。结果：发热家兔脑脊液PGE、cAMP含量异常升高(P<0.01)，AFMI可显著降低发热家兔脑脊液中异常升高的PGE和cAMP的含量(P<0.01)，最佳剂量为26.25 g*kg－1, 提前应用AFMI,可阻抑感染家兔脑脊液中PGE、cAMP的合成释放。结论：AFMI具有良好的解热降温作用。
목적：관찰항고열I호합제(AFMI)대발열가토뇌척액전렬선소E(PGE)、배린산선감(cAMP)함량적영향。방법：용폐염쌍구균감염가토，조성발열모형，제전응용AFMI합제급이량충불동제량우가토체온체도고봉시응용，관측가토뇌척액PGE、cAMP함량적변화병진행비교。결과：발열가토뇌척액PGE、cAMP함량이상승고(P<0.01)，AFMI가현저강저발열가토뇌척액중이상승고적PGE화cAMP적함량(P<0.01)，최가제량위26.25 g*kg－1, 제전응용AFMI,가조억감염가토뇌척액중PGE、cAMP적합성석방。결론：AFMI구유량호적해열강온작용。
OBJECTIVE:To study effects of Anti-fever mixture I(AFMI,composed of Herba Ephedrae Decoction and Radix Puerariae Decoction) to the levels of PGE and cAMP in the cerebrospinal fluid of fever rabbits.METHODS:Rabbits were infected by pneumococcus to produce a fever model. Two different doses of AFMI were used when the rabbits' temperature reached its peak, and also used AFMI ahead of schedule. Survey the changes of PGE and cAMP levels and compared with each other.RESULTS:The levels of PGE and cAMP in fever rabbits' cerebrospinal fluid was rised abnormally(P<0.01), AFMI can lower the abnormally rised levels of PGE and cAMP in the cerebrospinal fluid(P<0.01), and the use of AFMI ahead of schedule can inhibit the synthesis and release of PGE and cAMP in the cerebrospinal fluid.CONCLUSION:The antipyretic and lowering temperature effects of AFMI are excellent.