CAJ | 학술논문

观察脑梗死(CI)患者神经肽Y(NPY)、神经降压素(NT)、胃动素(MTL)、降钙素基因相关肽(CGRP)浓度变化及其临床意义。方法：选择C162例，用放免法检测血浆NPY、NT、MTL与CGRP浓度。结果：NPY、NT与MTL浓度显著高于对照组(P<0.0001)；于发病后24h内显著升高，7d内达高峰，8～15d开始下降，15d后仍在较高水平。NPY浓度重型与大灶组显著高于轻型(P<0.05)与小灶组(P<0.01)；发病积分≥6分组显著高于<6分组(P<0.05)；高血压组显著高于正常血压组(P<0.05)。NT与MTL浓度重型组显著高于中(P<0.05)、轻型组(P<0.01)；高血糖组显著高于正常血糖组(P<O.01)。CGRP浓度显著低于对照组(P<0.0001)，发病24h内即显著降低，2～7d进一步降低，8～15d开始升高，15d后逐渐升至正常水平。重型与大灶组显著高于轻型(P<0.0001)、中型(P<0.01)与小灶组(P<0.01)；伴发病积分≥6分组显著低于<6分组(P<0.05)。结论：CI患者NPY、NT、MTL、CGRP浓度变化以7d内最显著，15d后逐渐恢复正常水平；四种浓度监测可作为判断CI患者病情严重程度、病灶大小及伴发病的实验室指标。
관찰뇌경사(CI)환자신경태Y(NPY)、신경강압소(NT)、위동소(MTL)、강개소기인 상관태(CGRP)농도변화급기림상의의。방법：선택C162례，용방면법검측혈장NPY、NT、MTL여CGRP농도。결과：NPY、NT여MTL농도현저고우대조조(P<0.0001)；우발병후24h내현저승고，7d내체고봉，8～15d개시하강，15d후잉재교고수평。NPY농도중형여대조조현저고우경형(P<0.05)여소조조(P<0.01)；발병적분≥6분조현저고우<6분조(P<0.05)；고혈압조현저고우정상혈압조(P<0.05)。NT여MTL농도중형조현저고우중(P<0.05)、경형조(P<0.01)；고혈당조현저고우정상혈당조(P<O.01)。CGRP농도현저저우대조조(P<0.0001)，발병24h내즉현저강저，2～7d진일보강저，8～15d개시승고，15d후축점승지정상수평。중형여대조조현저고우경형(P<0.0001)、중형(P<0.01)여소조조(P<0.01)；반발병적분≥6분조현저저우<6분조(P<0.05)。결론：CI환자NPY、NT、MTL、CGRP농도변화이7d내최현저，15d후축점회복정상수평；사충농도감측가작위판단CI환자병정엄중정도、병조대소급반발병적실험실지표。
To observe level changes of neuropeptide Y (NPY), neurotensin (NT), motilin (MTL) and calcitonin gene-related peptide (CGRD) in plasma of patients with cerebral infarction and their clin ical significance. Methods:The levels of above indicators were measured by radioimmunoassay in 62 cases (test group) with cerebral infarction and 28 subjects as the normal control. Results: In test group,the levels of DPY, NT,and MTL increased more than those in control group(P<0.0001). They started to increase significantly during the first day,and began to decrease seven days later. The level of CGRP had a contrary change with levels of NPY, NT,and MTL. There was a significant correlation between those indicators and some complicated diseases of cerebral infarction( P<0.05). Conclusion: The level changes of DPY, NT, MTL, and CGRP in patients with cerebral infarction were most significant in 7 days,and gradually recovered to normal levels 15 days later. They may be used as laboratory markers for severity of patient's condition,bulk of cerebral infarction and some complicated diseases