复旦学报(医学版)
複旦學報(醫學版)
복단학보(의학판)
FUDAN UNIVERSITY JOURNAL OF MEDICAL SCIENCES
2005年
4期
451-454
,共4页
周亚刚%刘立根%施劲东%朱宏钧%蒋克泉%伍旭升%曹健敏
週亞剛%劉立根%施勁東%硃宏鈞%蔣剋泉%伍旭升%曹健敏
주아강%류립근%시경동%주굉균%장극천%오욱승%조건민
心房颤动%组织因子%组织因子途径抑制物%血栓形成%发病机制
心房顫動%組織因子%組織因子途徑抑製物%血栓形成%髮病機製
심방전동%조직인자%조직인자도경억제물%혈전형성%발병궤제
目的检测心房颤动(AF)患者血浆组织因子(TF)和组织因子途径抑制物(TFPI)抗原的变化,探讨组织因子凝血途径在心房血栓形成机制中的作用.方法选择心房颤动患者64例,采用酶联免疫吸附(ELISA)方法测定血浆TF和TFPI抗原水平,并与对照组进行比较.结果①与正常对照组比较,AF组血浆TF抗原水平显著增高[(1 060.0±669.8)pg/mL vs (423.6±245.1)pg/mL,P=0.000],总TFPI和游离TFPI抗原水平降低[(38.2±8.9)ng/mL vs(70.1±24.0)ng/mL,P=0.000;(26.3±8.0)ng/mL vs(41.2±16.7)ng/mL,P=0.000].②伴左房血栓心房颤动组与无左房血栓心房颤动组比较,伴左房血栓心房颤动组TF抗原水平显著增高[(1 431.4±564.5)pg/mL vs(904.6±660.3)pg/mL,P=0.004],总TFPI和游离TFPI抗原水平降低[(33.1±9.6)ng/mL vs(40.0±7.8)ng/mL,P=0.01;(22.9±8.2)ng/mL vs (22.7±7.4)ng/mL,P=0.048].结论心房颤动患者血浆组织因子途径改变表现为凝血活性增高和抗凝活性减低,组织因子凝血途径参与了心房颤动患者心房血栓形成机制.
目的檢測心房顫動(AF)患者血漿組織因子(TF)和組織因子途徑抑製物(TFPI)抗原的變化,探討組織因子凝血途徑在心房血栓形成機製中的作用.方法選擇心房顫動患者64例,採用酶聯免疫吸附(ELISA)方法測定血漿TF和TFPI抗原水平,併與對照組進行比較.結果①與正常對照組比較,AF組血漿TF抗原水平顯著增高[(1 060.0±669.8)pg/mL vs (423.6±245.1)pg/mL,P=0.000],總TFPI和遊離TFPI抗原水平降低[(38.2±8.9)ng/mL vs(70.1±24.0)ng/mL,P=0.000;(26.3±8.0)ng/mL vs(41.2±16.7)ng/mL,P=0.000].②伴左房血栓心房顫動組與無左房血栓心房顫動組比較,伴左房血栓心房顫動組TF抗原水平顯著增高[(1 431.4±564.5)pg/mL vs(904.6±660.3)pg/mL,P=0.004],總TFPI和遊離TFPI抗原水平降低[(33.1±9.6)ng/mL vs(40.0±7.8)ng/mL,P=0.01;(22.9±8.2)ng/mL vs (22.7±7.4)ng/mL,P=0.048].結論心房顫動患者血漿組織因子途徑改變錶現為凝血活性增高和抗凝活性減低,組織因子凝血途徑參與瞭心房顫動患者心房血栓形成機製.
목적검측심방전동(AF)환자혈장조직인자(TF)화조직인자도경억제물(TFPI)항원적변화,탐토조직인자응혈도경재심방혈전형성궤제중적작용.방법선택심방전동환자64례,채용매련면역흡부(ELISA)방법측정혈장TF화TFPI항원수평,병여대조조진행비교.결과①여정상대조조비교,AF조혈장TF항원수평현저증고[(1 060.0±669.8)pg/mL vs (423.6±245.1)pg/mL,P=0.000],총TFPI화유리TFPI항원수평강저[(38.2±8.9)ng/mL vs(70.1±24.0)ng/mL,P=0.000;(26.3±8.0)ng/mL vs(41.2±16.7)ng/mL,P=0.000].②반좌방혈전심방전동조여무좌방혈전심방전동조비교,반좌방혈전심방전동조TF항원수평현저증고[(1 431.4±564.5)pg/mL vs(904.6±660.3)pg/mL,P=0.004],총TFPI화유리TFPI항원수평강저[(33.1±9.6)ng/mL vs(40.0±7.8)ng/mL,P=0.01;(22.9±8.2)ng/mL vs (22.7±7.4)ng/mL,P=0.048].결론심방전동환자혈장조직인자도경개변표현위응혈활성증고화항응활성감저,조직인자응혈도경삼여료심방전동환자심방혈전형성궤제.