时珍国医国药
時珍國醫國藥
시진국의국약
LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH
2009年
7期
1753-1754
,共2页
四物汤%缺血损伤%脑
四物湯%缺血損傷%腦
사물탕%결혈손상%뇌
Siwutang%Ischemic injury%Brain
目的 探讨了中药方剂四物汤水煎液对永久性局部脑缺血损伤的保护作用.方法 通过颈内动脉放入二氧化钛球于大脑中动脉制造永久性局部脑缺血模型.在制备永久性局部脑缺血模型前2,4 h,分别以四物汤灌胃250 mg/(kg·ml).TTC染色,用图象分析系统确定梗塞面积.结果 口服四物汤明显减少大脑的梗塞面积.结论 传统中药四物汤水煎液具有抗脑缺血损伤作用.
目的 探討瞭中藥方劑四物湯水煎液對永久性跼部腦缺血損傷的保護作用.方法 通過頸內動脈放入二氧化鈦毬于大腦中動脈製造永久性跼部腦缺血模型.在製備永久性跼部腦缺血模型前2,4 h,分彆以四物湯灌胃250 mg/(kg·ml).TTC染色,用圖象分析繫統確定梗塞麵積.結果 口服四物湯明顯減少大腦的梗塞麵積.結論 傳統中藥四物湯水煎液具有抗腦缺血損傷作用.
목적 탐토료중약방제사물탕수전액대영구성국부뇌결혈손상적보호작용.방법 통과경내동맥방입이양화태구우대뇌중동맥제조영구성국부뇌결혈모형.재제비영구성국부뇌결혈모형전2,4 h,분별이사물탕관위250 mg/(kg·ml).TTC염색,용도상분석계통학정경새면적.결과 구복사물탕명현감소대뇌적경새면적.결론 전통중약사물탕수전액구유항뇌결혈손상작용.
Objective To evaluate the effects of water extract of Shiwutang (SWT) on neuronal death in permanent focal brain ischemia.Methods Three cerebrol macrospheres were injected into the internal carotid artery after ligation of the external carotid artery to induce permanent focal brain ischemic injury.SWT was given orally 2 h before and 4 h after induction of permanent focal brain ischemic injury.24th after permanent middle cerebral artery occlusion,TTC (2,3,5-triphenyltetrazolium chloride) staining was conducted to show train infarction region.Results Treatment with SWT significantly reduced infarction volume.Conclusion Water extract of SWT provides neuroprotection against ischemic injury.
