上海医学
上海醫學
상해의학
SHANGHAI MEDICAL JOURNAL
2009年
12期
1083-1085
,共3页
李青%吴松华%屠印芳%唐峻岭%潘洁敏%李鸣%周健%贾伟平%项坤三
李青%吳鬆華%屠印芳%唐峻嶺%潘潔敏%李鳴%週健%賈偉平%項坤三
리청%오송화%도인방%당준령%반길민%리명%주건%가위평%항곤삼
糖尿病%糖化血清白蛋白%糖化血红蛋白
糖尿病%糖化血清白蛋白%糖化血紅蛋白
당뇨병%당화혈청백단백%당화혈홍단백
Diabetes mellitus%Glycated albumin%Glycated hemoglobin
目的 检测2型糖尿病住院患者的糖化血清白蛋白(GA),评价GA作为一个反映短期平均血糖水平变化及住院期间血糖控制临床监测指标的可靠性.方法 收集上海交通大学附属第六人民医院内分泌代谢科2006年5月-2007年11月住院的445例2型糖尿病患者,测定空腹血糖(FPG)、餐后2 h血糖(2hPG)、1日指尖血糖谱均值(MBG)、GA、糖化血红蛋白(HbA_1c)等,并对其中101例住院近2周的患者在住院后第12天复查GA、HbA_1c、FPG、2hPG、MBG等指标,其中GA以液态酶法(GA-L)测定.结果 ①445例2型糖尿病患者中,GA与HbA,c(r=0.818)、FPG(r=0.573)、2hPG(r=0.409)、MBG(r=0.313)均呈正相关(P值均<0.01).②101例住院近2周的2型檐尿病患者人院后第12天的GA为(23.24±4.51)%,显著低于人院第1天的(30.10±6.75)%(P<0.01).③101例住院近2周的2型糖尿病患者人院后第12天的GA较入院第1天下降6.86%(P<0.01),平均降幅为21.19%;HbA_1c下降0.74%(P<0.01),平均降幅为6.38%.GA的降幅显著大于HbA_1c(P<0.01).结论 GA可准确、及时地反映短期内平均血糖水平的变化,比HbA_1c更适合作为评价2型糖尿病患者住院期间(12 d)降糖疗效的临床监测指标.
目的 檢測2型糖尿病住院患者的糖化血清白蛋白(GA),評價GA作為一箇反映短期平均血糖水平變化及住院期間血糖控製臨床鑑測指標的可靠性.方法 收集上海交通大學附屬第六人民醫院內分泌代謝科2006年5月-2007年11月住院的445例2型糖尿病患者,測定空腹血糖(FPG)、餐後2 h血糖(2hPG)、1日指尖血糖譜均值(MBG)、GA、糖化血紅蛋白(HbA_1c)等,併對其中101例住院近2週的患者在住院後第12天複查GA、HbA_1c、FPG、2hPG、MBG等指標,其中GA以液態酶法(GA-L)測定.結果 ①445例2型糖尿病患者中,GA與HbA,c(r=0.818)、FPG(r=0.573)、2hPG(r=0.409)、MBG(r=0.313)均呈正相關(P值均<0.01).②101例住院近2週的2型簷尿病患者人院後第12天的GA為(23.24±4.51)%,顯著低于人院第1天的(30.10±6.75)%(P<0.01).③101例住院近2週的2型糖尿病患者人院後第12天的GA較入院第1天下降6.86%(P<0.01),平均降幅為21.19%;HbA_1c下降0.74%(P<0.01),平均降幅為6.38%.GA的降幅顯著大于HbA_1c(P<0.01).結論 GA可準確、及時地反映短期內平均血糖水平的變化,比HbA_1c更適閤作為評價2型糖尿病患者住院期間(12 d)降糖療效的臨床鑑測指標.
목적 검측2형당뇨병주원환자적당화혈청백단백(GA),평개GA작위일개반영단기평균혈당수평변화급주원기간혈당공제림상감측지표적가고성.방법 수집상해교통대학부속제륙인민의원내분비대사과2006년5월-2007년11월주원적445례2형당뇨병환자,측정공복혈당(FPG)、찬후2 h혈당(2hPG)、1일지첨혈당보균치(MBG)、GA、당화혈홍단백(HbA_1c)등,병대기중101례주원근2주적환자재주원후제12천복사GA、HbA_1c、FPG、2hPG、MBG등지표,기중GA이액태매법(GA-L)측정.결과 ①445례2형당뇨병환자중,GA여HbA,c(r=0.818)、FPG(r=0.573)、2hPG(r=0.409)、MBG(r=0.313)균정정상관(P치균<0.01).②101례주원근2주적2형첨뇨병환자인원후제12천적GA위(23.24±4.51)%,현저저우인원제1천적(30.10±6.75)%(P<0.01).③101례주원근2주적2형당뇨병환자인원후제12천적GA교입원제1천하강6.86%(P<0.01),평균강폭위21.19%;HbA_1c하강0.74%(P<0.01),평균강폭위6.38%.GA적강폭현저대우HbA_1c(P<0.01).결론 GA가준학、급시지반영단기내평균혈당수평적변화,비HbA_1c경괄합작위평개2형당뇨병환자주원기간(12 d)강당료효적림상감측지표.
Objective To examine the serum glycated albumin (GA) level in diabetic inpatients and to assess its reliability as a clinical marker of short-term blood glucose level and blood glucose control of diabetic inpatients. Methods A total of 445 type 2 diabetic patients, who were treated in our in-patient department from May 2006 to November 2007, were enrolled in the present study. The fasting plasma glucose (FPG), post-prandial plasma glucose (2hPG), GA, and HbA_1c, were observed. The above parameters were measured again on day 12 of hospitalization in 101 patients who were treated for more than two weeks. GA-I technique was used to determine GA. Results ①The GA value was positively correlated with HbA_1c, FPG, 2hPG and MBG, with the coefficients being 0.818, 0.573, 0.409 and 0.313, respectively (P<0.01). ② The GA level in 101 patients was ([23.24±4.51]%) 12 days after admission, significantly lower than that on the first day of admission ([30.10 ± 6.75]%, P<0.01). ③The GA level decreased by 6.86 % in the 101 patients on day 12 of admission compared with that of the pre-treatment level (P<0.01), with a mean cutting down of 21.19%;and the HbA_1c value decreased by 0.74% (P<0.01), with a mean cutting down of 6.38%. The decrease degree of GA was more severe that that of HbA_1c (P < 0.01). Conclusion GA can accurately, promptly reflect the change of mean glycemic level. Compared with HbA_1c, GA is a more suitable clinical monitoring marker for evaluating the glucose control in diabetic inpatients.
