CAJ | 학술논문

目的探讨卡培他滨(CAP)与放射联合对子宫颈腺癌裸鼠移植瘤的抑制效果.方法将接种CAC-1细胞的裸鼠随机分成对照组、CAP组、5.氟尿嘧啶(5-FU)组、放射组、CAP+放射组、5-FU+放射组,并设肿瘤大小不同的两大组,将大、小瘤组又分出对照组、CAP组、放射组、CAP+放射组.观察肿瘤体积变化,计算增殖百分率,推算肿瘤生长延迟时间.结果 2/3 MTD CAP+放射(6 Gy、2 Gy/d×8次)联合治疗组与对照组、单纯药物组及单纯放射组相比,联合治疗效果显著(P<0.05),明显强于2/3MTD5-FU+6 Gy的抑制效果,其中cAP+2 Gy/d×8次的疗效最为突出;大瘤组肿瘤对联合治疗效果明显(P<0.05),小瘤组肿瘤对联合治疗反应性差.结论 CAP与放射联合应用对子宫颈腺癌CAC-1裸鼠移植瘤有明显抑制效果,两者之间具有协同作用,并受放射剂量、放射方式影响,也可能受肿瘤大小影响.
목적 탐토잡배타빈(CAP)여방사연합대자궁경선암라서이식류적억제효과.방법 장접충CAC-1세포적라서수궤분성대조조、CAP조、5.불뇨밀정(5-FU)조、방사조、CAP+방사조、5-FU+방사조,병설종류대소불동적량대조,장대、소류조우분출대조조、CAP조、방사조、CAP+방사조.관찰종류체적변화,계산증식백분솔,추산종류생장연지시간.결과 2/3 MTD CAP+방사(6 Gy、2 Gy/d×8차)연합치료조여대조조、단순약물조급단순방사조상비,연합치료효과현저(P<0.05),명현강우2/3MTD5-FU+6 Gy적억제효과,기중cAP+2 Gy/d×8차적료효최위돌출;대류조종류대연합치료효과명현(P<0.05),소류조종류대연합치료반응성차.결론 CAP여방사연합응용대자궁경선암CAC-1라서이식류유명현억제효과,량자지간구유협동작용,병수방사제량、방사방식영향,야가능수종류대소영향.
Objective To observe the therapeutic effect of the new plan of concurrent capecitabine (CAP) and radiation therapy for hu-man cervical adenocarcinoma in nude mice. Methods The nude mice were injected with CAC-1 cells for the modelization of cervical ade-nocarcinoma. Before treatment,all mice with tumors were randomly divided into control group,CAP group,5-FU group,radiation group,CAP+ radiation group,5-FU+radiation group. According to the tumor size,mice were furtherly divided into large-size and small-size groups in the control group,CAP group,radiation group, CAP+radiation group. The change of tumor size,tumor growth percentage and the delay time of tu-mor growth were evaluated. Results The therapeutic effect of combining 2/3MTD CAP with 6 Gy radiation or fractionation 2 Gy × 8 times radiation was better than that of the control group,chemotherapy group and the radiation group. The difference was significant (P < 0.05). The restraint effect of the combining 2/3MTD CAP with 6 Gy radiotherapy was better than that of the combining 2/3MTD 5-FU with 6 Gy radiotherapy. Combining 2/3MTD CAP with fractionation 2 Gyx8 times radiation therapy was more efficient than Combining 2/3MTD CAP with fractionation 6 Gy radiation therapy. In combining therapy groups,the response of large-size tumors was more significant than that of the small-size tumors (P < 0.05),which had almost no obvious response. Conclusion Concurrent CAP and radiation therapy has obvious restraint effect on CAC-1 cervix adenocarcinoma in nude mice. The CAP and radiation therapy can promote the therapeutic effect to each oth-er. The therapeautic effect of the concurrent CAP and radiation therapy is affected by the radiation dose, radiation method and the tumor size.