云南省富源地区肺癌危险因素的Meta分析
운남성부원지구폐암위험인소적Meta분석
Meta analysis of risk factors for lung cancer in Fuyuan of Yunnan province
  • 万方数据
    国际呼吸杂志 국제호흡잡지
    INTERNATIONAL JOURNAL OF RESPIRATION
    2012年 15期 1134-1138 ,共5页

    余君%王玉琦%秦新裕%樊嘉%高光所%罗光雄%马开祥%罗艳%李才花%毛亚莲%赵瑜淑%胡蕊%魏宁%杨震%唐红敏%蒋奕%张建平%李远方%饶圣祥%胡洁%洪群英%宋元林%白春学

    여군%왕옥기%진신유%번가%고광소%라광웅%마개상%라염%리재화%모아련%조유숙%호예%위저%양진%당홍민%장혁%장건평%리원방%요골상%호길%홍군영%송원림%백춘학

    肺癌%危险因素%Meta分析%富源地区 肺癌%危險因素%Meta分析%富源地區
    폐암%위험인소%Meta분석%부원지구
    Lung cancer%Risk factors%Meta analysis%Fuyuan area
    目的 云南省富源县是中国肺癌高发地区之一,探讨该地区人群肺癌发生的危险因素,为肺癌的预防控制提供科学依据.方法 通过Pubmed、Web of knowledge、Google、中国期刊全文数据库和万方数据资源系统等检索1995年1月至2011年12月公开发表的关于该地区人群肺癌发病危险因素的国内外研究文献,采用RevMan4.2软件进行Meta分析.结果 共纳入12篇文献,累计病例4 666例,对照5 298例.各因素合并比值比分别为生活用煤(4.40)、居室通风情况(2.15)、炼煤环境(2.02)、吸烟(1.72)、女性被动吸烟(1.70)、易感基因(肿瘤家族史)(1.65)、慢性呼吸道疾病(1.52)、饮食习惯(饮酒和高脂饮食)(1.39)、蔬果摄人多(0.65).结论 影响富源地区人群肺癌发生的危险因素为室内外环境污染、吸烟、家族史、呼吸系统疾病和饮食习惯等,提示环境因素和遗传因素在该地区肺癌的发病中有重要作用.
    목적 운남성부원현시중국폐암고발지구지일,탐토해지구인군폐암발생적위험인소,위폐암적예방공제제공과학의거.방법 통과Pubmed、Web of knowledge、Google、중국기간전문수거고화만방수거자원계통등검색1995년1월지2011년12월공개발표적관우해지구인군폐암발병위험인소적국내외연구문헌,채용RevMan4.2연건진행Meta분석.결과 공납입12편문헌,루계병례4 666례,대조5 298례.각인소합병비치비분별위생활용매(4.40)、거실통풍정황(2.15)、련매배경(2.02)、흡연(1.72)、녀성피동흡연(1.70)、역감기인(종류가족사)(1.65)、만성호흡도질병(1.52)、음식습관(음주화고지음식)(1.39)、소과섭인다(0.65).결론 영향부원지구인군폐암발생적위험인소위실내외배경오염、흡연、가족사、호흡계통질병화음식습관등,제시배경인소화유전인소재해지구폐암적발병중유중요작용.
    Objective Fuyuan is one of the areas with highest prevalence of lung cancer in China.The present study analyzed the main risk factors for high incidence of lung cancer in Fuyuan to direct future lung cancer prevention.Methods We reviewed previous studies on lung cancer in Fuyuan of Yunnan province from January 1995 to December 2011.by searching Pubmed,Web of knowledge,Google,Chinese National Knowledge Infrastructure and ChinaInfo.The Meta analysis was done using RevMan 4.2.Results A total of 12 studies involving 4666 patients and 5298 controls were included.The pooled odd ratio (OR) values were 4.40 (indoor coal pollution),2.15 (ventilation in kitchen),2.02(exposure to coal-mine production),1.72 (smoking),1.70 (second hand smoke for women),1.65(genetic susceptibility,family history),1.52 ( certain pulmonary diseases),1.39 (diet,cholesterol,alcohol),and 0.65 (vegetables and fruits).Conclusions The main risk factors for lung cancer are environmental pollution,smoking,family history,certain pulmonary diseases and diet.Environmental pollution and genetics contribute to development of lung cancer in Fuyuan of Yunnan province in China.
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