CAJ | 학술논문

目的探讨缺血性心肌病(ICM)患者血红蛋白、细胞因子水平与心功能变化的相关性.方法测定121例CHF患者的血红蛋白(Hb)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的变化;超声心动图测量左室射血分数(LVEF),评价心功能;按Hb水平分为ICM贫血组和非贫血组,同时选择27例正常人作为对照组.结果 ICM贫血组TNF-α、IL-6明显高于非贫血组,而LVEF显著低于非贫血组(P＜0.01);随着TNF-α、IL-6水平升高,Hb和LVEF明显降低(P＜0.01);ICM患者Hb和LVEF与TNF-α、IL-6水平呈负相关,Hb水平与LVEF呈正相关(P＜0.01).结论细胞因子影响并促进ICM患者贫血与心力衰竭相互作用的病理生理过程.
목적 탐토결혈성심기병(ICM)환자혈홍단백、세포인자수평여심공능변화적상관성.방법 측정121례CHF환자적혈홍단백(Hb)、종류배사인자-α(TNF-α)、백세포개소-6(IL-6)적변화;초성심동도측량좌실사혈분수(LVEF),평개심공능;안Hb수평분위ICM빈혈조화비빈혈조,동시선택27례정상인작위대조조.결과 ICM빈혈조TNF-α、IL-6명현고우비빈혈조,이LVEF현저저우비빈혈조(P＜0.01);수착TNF-α、IL-6수평승고,Hb화LVEF명현강저(P＜0.01);ICM환자Hb화LVEF여TNF-α、IL-6수평정부상관,Hb수평여LVEF정정상관(P＜0.01).결론 세포인자영향병촉진ICM환자빈혈여심력쇠갈상호작용적병리생리과정.
Objective To study the relationships between hemoglobin concentration,cytokine and cardiac function in patients with ischemic cardiomyopathy.Methods Hemoglobin concentration,sernm TNF-α,IL-6 in 121 patients with ischemic cardiomyopathy were measured,left ventricular ejection fraction(LVEF)by echocardiography,according to hemoglobin concentration,these patients were distributed to the anemic group and the non-anemic group,contrasting to 27 healthy persons.Results The levels of serum TNF-α,IL-6 in the anemic patients group were higher than those in the non-anemic group subjects,but LVEF Wag lower.With the increase of anemia severity,the levels of serum TNF-α,IL-6 significantly increased;there was a positive correlation between LVEF and the levels of serum TNF-α,IL-6(P＜0.01),and a negative correlation between LVEF and Hb concentration.Conclusion The levels of cytokine promote the pathophysiological procedure between cardiac failure and anemic in ICM.