CAJ | 학술논문

目的探讨声触诊组织量化(virtual touch tissues quantification,VTQ)技术检测移植肝急性排异的可行性.方法 118名患者分为4组:正常对照组31例,肝硬化患者29例,移植肝急性排异患者28例,无并发症移植肝患者30例,排异患者均有肝穿刺病理检查证实,余患者经临床随访证实.应用超声VTQ技术检测研究对象的肝右叶,获取VTQ值并对不同组间进行比较.结果正常人肝VTQ值为(1.10±0.29)m/s,移植肝无并发症者VTQ值为(1.33±0.33)m/s,移植肝急性排异者VTQ值为(1.81±0.47)m/s,肝硬化患者VTQ值(2.12±0.59)m/s.各组间VTQ值两两比较,差异均有显著统计意义(P＜0.01);VTQ值的升高对移植肝排异具有一定的判别能力(P＜0.01).以移植肝右叶VTQ值＞1.36m/s提示移植肝急性排异可能,诊断灵敏性为82.1％,特异性为68.2％.结论声触诊组织量化技术对于评价移植肝急性排异的发生有一定临床应用价值.
목적 탐토성촉진조직양화(virtual touch tissues quantification,VTQ)기술검측이식간급성배이적가행성.방법 118명환자분위4조:정상대조조31례,간경화환자29례,이식간급성배이환자28례,무병발증이식간환자30례,배이환자균유간천자병리검사증실,여환자경림상수방증실.응용초성VTQ기술검측연구대상적간우협,획취VTQ치병대불동조간진행비교.결과 정상인간VTQ치위(1.10±0.29)m/s,이식간무병발증자VTQ치위(1.33±0.33)m/s,이식간급성배이자VTQ치위(1.81±0.47)m/s,간경화환자VTQ치(2.12±0.59)m/s.각조간VTQ치량량비교,차이균유현저통계의의(P＜0.01);VTQ치적승고대이식간배이구유일정적판별능력(P＜0.01).이이식간우협VTQ치＞1.36m/s제시이식간급성배이가능,진단령민성위82.1％,특이성위68.2％.결론 성촉진조직양화기술대우평개이식간급성배이적발생유일정림상응용개치.
Objective To investigate the viability of virtual touch tissue quantification (VTQ)technique in the prediction of acute rejection in transplanted liver.Methods One hundred and eighteen patients enrolled in the study were categorized into four groups:normal control (n =31),cirrhosis ( n =29),transplanted liver with acute rejection (n =28),transplant liver without any complications (n =30).All the patients were confirmed by pathology or clinical results.The VTQ of right robe of liver was obtained by a ultrasound system with VTQ technique and the data was compared among the four groups.Results The VTQ was (1.10 ± 0.29)m/s,(1.33 ± 0.33) m/s,(1.81 ± 0.47) m/s and (2.12 ± 0.59) m/s in normal control,transplanted liver without any complications,transplanted liver with acute rejection and cirrhosis group,respectively.It was significantly different in all four groups (P＜0.01).Patients with acute rejection were associated with the increase of the VTQ values (P＜0.01).Using a cutoff of VTQ＞1.36 m/s measured in the transplanted liver for prediction of acute rejection,the sensitivity and specificity were 82.1％ and 68.2％.Conclusions VTQ technique may have some clinical value in evaluation the acute rejection in transplanted liver.