CAJ | 학술논문

目的分析男性代谢综合征(MS)患者青春期子代和健康人青春期子代的MS各组分及血清超敏C反应蛋白(hs-CRP)等疾病表型的差异,探讨MS及其相关组分的家族聚集特征.方法采用遗传流行病学1:3病例对照家系设计,确定26例男性MS作为先证者(病例组)以及78名健康人作为对照组.通过体格检查和实验室检查收集两组研究对象青春期子代的疾病表型信息.测定身高、体重、腰围、臀围、血压,计算BMI、腰臀比和腰围身高比.实验室检测空腹血糖、血脂四项及血清hs-CRP含量.结果 MS病例组青春期子代的肥胖指标(腰围、腰围身高比、腰臀比、DBP值)及hs-CRP值均高于对照组的青春期子代(P＜0.05).病例组青春期子代的MS、中心性肥胖率以及血脂异常率(低HDL-C)均高于对照组子代(P＜0.05).并且病例组子代患MS组分数量显著高于对照组(r=0.231,P＜0.05).结论病例与对照组青春期子代的疾病表型存在差异;提示MS的家族聚集性在青春期即已体现,主要表现在中心性肥胖、血压升高和炎症表达明显.
목적 분석남성대사종합정(MS)환자청춘기자대화건강인청춘기자대적MS각조분급혈청초민C반응단백(hs-CRP)등질병표형적차이,탐토MS급기상관조분적가족취집특정.방법 채용유전류행병학1:3병례대조가계설계,학정26례남성MS작위선증자(병례조)이급78명건강인작위대조조.통과체격검사화실험실검사수집량조연구대상청춘기자대적질병표형신식.측정신고、체중、요위、둔위、혈압,계산BMI、요둔비화요위신고비.실험실검측공복혈당、혈지사항급혈청hs-CRP함량.결과 MS병례조청춘기자대적비반지표(요위、요위신고비、요둔비、DBP치)급hs-CRP치균고우대조조적청춘기자대(P＜0.05).병례조청춘기자대적MS、중심성비반솔이급혈지이상솔(저HDL-C)균고우대조조자대(P＜0.05).병차병례조자대환MS조분수량현저고우대조조(r=0.231,P＜0.05).결론 병례여대조조청춘기자대적질병표형존재차이;제시MS적가족취집성재청춘기즉이체현,주요표현재중심성비반、혈압승고화염증표체명현.
Objective To analyze the impact of parental Metabolic Syndrome(MS)on adolescents,and to explore the familial aggregation of MS with its components.Methods Using a 1:3 case-control familial study design to choose 26 MS male patients as proband and 78 healthy men as controls.Data regarding phenotype of their adolescence offspring were collected.Height,weight,waist circumference(WC),blood pressure,body mass index(BMI),waist-to-hip ratio(WHR)and waist-to-height ratio(WHtR)were measured or calculated.FPG,TC,TG,HDL-C and LDL-C were detected by automatic biochemical analyzer and hs-CRP was detected.Results WC,WHtR,WHR,DBP and hs-CRP of those adolescents with paternal MS were significantly higher than in controls(P＜0.05).Rates of MS,Obesity depend WC,low level of HDL-C of adolescent with paternal MS were significantly higher than in controls(P＜0.05).The rate of number on MS was significantly higher in case group than in control(r=0.231,P＜0.05).Conclusion The phenotypes of MS were different between adolescents with or without parental MS,indicating that the familial aggregation of MS had been existed in their adolescent offspring,and mainly presented in central obesity,increased blood pressure and inflammation.