CAJ | 학술논문

角蒿(Incarvillea sinensis)为透骨草的主要来源之一,称为"羊角透骨草",具有祛风除湿、消肿止痛之功效.从其全草分离得到了多种新的单萜生物碱和大环精胺类生物碱,其中单萜生物碱之一角蒿酯碱(incarvillateine),具有很强的镇痛活性,且作用机理不同于吗啡.角蒿酯碱已成为开发新型非麻醉性镇痛新药的重要先导化合物,本文对角蒿的化学成分、镇痛活性、作用机理和构效关系的研究作一综述.
각호(Incarvillea sinensis)위투골초적주요래원지일,칭위"양각투골초",구유거풍제습、소종지통지공효.종기전초분리득도료다충신적단첩생물감화대배정알류생물감,기중단첩생물감지일각호지감(incarvillateine),구유흔강적진통활성,차작용궤리불동우마배.각호지감이성위개발신형비마취성진통신약적중요선도화합물,본문대각호적화학성분、진통활성、작용궤리화구효관계적연구작일종술.
Incarvillae sinensis LAM., a traditional Chinese medicine, has been used to treat rheumatism and to relieve pain.From the whole plants,a number of novel monoterpene alkaloids and macrocyclic spermine alkaloids have been identified. Oneof the monoterpene alkaloids, incarvillateine, demonstrated higher antinociceptive effect than morphine in the formalin test, andthe mechanism of antinociception was different from that of morphine. Incarvillateine has become an important lead compoundfor developing new natural medicinal drugs.In this paper,the chemical investigation as well as the biological activity and struc-ture-activity relationship were reviewed.