CAJ | 학술논문

目的:探讨转化生长因子β1(transforming growth factor β1,TGF-β1)基因多态性与脑梗死的关系.方法:利用多聚酶链反应-限制性片段长度多态性分析法检测247例脑梗死(cerebral infarction, CI)患者及167例性别、年龄匹配的健康体检者-800G>A多态位点的基因型,并计算出各等位基因频率在组中的频率分布.结果:中国湖南汉族人群中存在-800G>A位点多态性.-800G>A基因型在两个人群中的分布符合Hardy-Weinberg平衡,脑梗死组与对照组相比,基因型及等位基因频率分布无统计学差异(P>0.05),Logistic回归分析未发现某种基因型增加或者降低脑梗死发生的风险.结论:TGF-β1-800G>A基因多态性与中国湖南地区汉族人群脑梗死无明显相关性.
목적:탐토전화생장인자β1(transforming growth factor β1,TGF-β1)기인다태성여뇌경사적관계.방법:이용다취매련반응-한제성편단장도다태성분석법검측247례뇌경사(cerebral infarction, CI)환자급167례성별、년령필배적건강체검자-800G>A다태위점적기인형,병계산출각등위기인빈솔재조중적빈솔분포.결과:중국호남한족인군중존재-800G>A위점다태성.-800G>A기인형재량개인군중적분포부합Hardy-Weinberg평형,뇌경사조여대조조상비,기인형급등위기인빈솔분포무통계학차이(P>0.05),Logistic회귀분석미발현모충기인형증가혹자강저뇌경사발생적풍험.결론:TGF-β1-800G>A기인다태성여중국호남지구한족인군뇌경사무명현상관성.
Objective To investigate the association between transforming growth factor β1(TGF-β1)-800G>A polymorphism and cerebral infarction(CI). Methods The genotypes of 247 patients with atherosclerotic cerebral infarction and 167 sex- and age-matched healthy controls were detected by PCR-RFLP, and the frequency distribution of alleles calculated. Results TGF-β1-800G>A polymorphism was found in Han population in Hunan Province, China. The distribution of -800G>A genotypes was consistent with Hardy-Weinberg balance in the CI and healthy control group. There was no significant difference between genotypes and allele frequency of TGF-β1-800G>A in the CI and control group (P>0.05). Logistic regression analysis suggested that no genotypes could increase or reduce the risk of CI onset (P>0.05). Conclusion TGF-β1-800G>A polymorphism is not associated with CI in Han population in Hunan Province.