中国癌症杂志
中國癌癥雜誌
중국암증잡지
CHINA ONCOLOGY
2010年
3期
222-226
,共5页
CXCR4%CXCR7%CXCL12%肿瘤%趋化因子受体
CXCR4%CXCR7%CXCL12%腫瘤%趨化因子受體
CXCR4%CXCR7%CXCL12%종류%추화인자수체
CXCR4%CXCR7%CXCL12%cancer%chemokine receptor
以往的研究认为趋化因子受体4(chemokine receptor 4,CXCR4)是趋化因子CXCL12的唯一受体,CXCL12/CXCR4生物轴在肿瘤发展过程中起重要作用,然而最近研究发现CXCL12尚存在CXCR7这一新的受体,并且CXCL12/CXCR7生物轴同样对肿瘤的发生发展起重要作用.本文就有关趋化因子受体CXCR4和CXCR7在肿瘤中的表达、促进肿瘤增殖和转移、促进血管新生以及肿瘤治疗等方面的研究作一综述.
以往的研究認為趨化因子受體4(chemokine receptor 4,CXCR4)是趨化因子CXCL12的唯一受體,CXCL12/CXCR4生物軸在腫瘤髮展過程中起重要作用,然而最近研究髮現CXCL12尚存在CXCR7這一新的受體,併且CXCL12/CXCR7生物軸同樣對腫瘤的髮生髮展起重要作用.本文就有關趨化因子受體CXCR4和CXCR7在腫瘤中的錶達、促進腫瘤增殖和轉移、促進血管新生以及腫瘤治療等方麵的研究作一綜述.
이왕적연구인위추화인자수체4(chemokine receptor 4,CXCR4)시추화인자CXCL12적유일수체,CXCL12/CXCR4생물축재종류발전과정중기중요작용,연이최근연구발현CXCL12상존재CXCR7저일신적수체,병차CXCL12/CXCR7생물축동양대종류적발생발전기중요작용.본문취유관추화인자수체CXCR4화CXCR7재종류중적표체、촉진종류증식화전이、촉진혈관신생이급종류치료등방면적연구작일종술.
CXCR4 has long been considered as the unique receptor of CXCL12,and CXCL12/CXCR4 axis plays a prominent role in tumorigenesis.However,a novel receptor for CXCL12,named CXCR7,has been recently identified and also plays an important role in tumorigenesis.This review summarized current studies regarding the functions of CXCR4 and CXCR7 in cancer and the recent therapeutic approaches that target these receptors or their ligands.
