中华内分泌外科杂志
中華內分泌外科雜誌
중화내분비외과잡지
CHINESE JOURNAL OF ENDOCRINE SURGERY
2010年
5期
295-298
,共4页
尹华山%董国民%魏怀芬%王延东
尹華山%董國民%魏懷芬%王延東
윤화산%동국민%위부분%왕연동
散发性乳腺癌%BRCA1%BRCA2
散髮性乳腺癌%BRCA1%BRCA2
산발성유선암%BRCA1%BRCA2
Sporadic breast carcinoma%BRCA1%BRCA2
目的 探讨BRCA1和BRCA2在胶东半岛地区女性散发性乳腺癌组织中的表达特点及其临床意义.方法 应用组织芯片技术及免疫组织化学方法检测100例胶东半岛地区女性散发性乳腺癌及30例乳腺良性病变组织中BRCA1和BRCA2的表达.结果 ①BRCA1和BRCA2的阳性表达率在乳腺癌组织中分别为49%(49/100)和50%(50/100);在乳腺良性病变中分别为80%(24/30)、83 33%(25/30).二者差异有统计学意义(P＜0.05).②乳腺癌组织中BRCA1和BRCA2的表达与患者年龄、淋巴结转移状况、肿瘤的大小及绝经与否差异均无统计学意义(P＞0.05).③BRCA1 和BRCA2 在乳腺癌中的表达无相关性.结论 BRCA1和BRCA2在胶东半岛地区散发性乳腺癌组织中的表达明显低于乳腺良性病变,可作为胶东半岛地区散发性乳腺癌监测指标,但在散发性乳腺癌发生发展中的作用是独立的,不具有相关性.
目的 探討BRCA1和BRCA2在膠東半島地區女性散髮性乳腺癌組織中的錶達特點及其臨床意義.方法 應用組織芯片技術及免疫組織化學方法檢測100例膠東半島地區女性散髮性乳腺癌及30例乳腺良性病變組織中BRCA1和BRCA2的錶達.結果 ①BRCA1和BRCA2的暘性錶達率在乳腺癌組織中分彆為49%(49/100)和50%(50/100);在乳腺良性病變中分彆為80%(24/30)、83 33%(25/30).二者差異有統計學意義(P＜0.05).②乳腺癌組織中BRCA1和BRCA2的錶達與患者年齡、淋巴結轉移狀況、腫瘤的大小及絕經與否差異均無統計學意義(P＞0.05).③BRCA1 和BRCA2 在乳腺癌中的錶達無相關性.結論 BRCA1和BRCA2在膠東半島地區散髮性乳腺癌組織中的錶達明顯低于乳腺良性病變,可作為膠東半島地區散髮性乳腺癌鑑測指標,但在散髮性乳腺癌髮生髮展中的作用是獨立的,不具有相關性.
목적 탐토BRCA1화BRCA2재효동반도지구녀성산발성유선암조직중적표체특점급기림상의의.방법 응용조직심편기술급면역조직화학방법검측100례효동반도지구녀성산발성유선암급30례유선량성병변조직중BRCA1화BRCA2적표체.결과 ①BRCA1화BRCA2적양성표체솔재유선암조직중분별위49%(49/100)화50%(50/100);재유선량성병변중분별위80%(24/30)、83 33%(25/30).이자차이유통계학의의(P＜0.05).②유선암조직중BRCA1화BRCA2적표체여환자년령、림파결전이상황、종류적대소급절경여부차이균무통계학의의(P＞0.05).③BRCA1 화BRCA2 재유선암중적표체무상관성.결론 BRCA1화BRCA2재효동반도지구산발성유선암조직중적표체명현저우유선량성병변,가작위효동반도지구산발성유선암감측지표,단재산발성유선암발생발전중적작용시독립적,불구유상관성.
Objective To study the expression and clinical significance of BRCA1 and BRCA2 in sporadic breast cancer in women of Jiaodong peninsula. Methods Immunohistochemistry and tissue array were used to detect the expression of BRCA1 and BRCA2 in 100 cases of sporadic breast cancer and 30 cases of benign breast tumor in women of Jiaodong peninsula. Results ① The expression rate of BRCA1 and BRCA2 was 49% (49/100) and 50% (50/100) in breast cancer, 80% (24/30) and 83.33% (25/30) in benign breast lesions respectively. The expression rate of BRCA1 and BRCA2 in breast cancer was lower than that in benign breast lesions (P<0.05). ② The expression of BRCA1 and BRCA2 was uncorrelated with factors such as tumor size, lymphatic metastases, age and menopause or not(P>0.05). ③ There was no dependency between the expression of BRCA1 and BRCA2 (P> 0. 05). Conclusions The expression rate of BRCA1 and BRCA2 in breast carcinoma in women of Jiaodong peninsula was lower than that in benign breast lesions, suggesting that the expression of BRCA1 and BRCA2 was related to the occurrence of sporadic breast carcinoma in women of Jiaodong peninsula. However, the role of BRCA1 and BRCA2 in the genesis and development of the breast carcinoma is independent.
