CAJ | 학술논문

目的比较渐进镜和单焦点眼镜在延缓学龄儿童近视进展中的效果.方法 Meta分析.系统检索电子数据库Medline、EMBASE、Cochrane Library、中国生物医学文献数据库和中国临床试验注册中心中关于渐进镜的随机对照研究,手工检索相关书籍期刊,双人独立筛选评估文献和进行数据提取,以屈光度变化量、眼轴长度变化量和玻璃体腔长度变化量为结局变量进行Meta分析.结果总共有5项符合标准的随机对照研究被纳入Meta分析,总样本量为1077例.对比渐进镜和单焦点眼镜采用固定效应模型分析,二者在延缓学龄儿童近视的屈光度进展量的加权均数差为-0.22 D(95％CI:-0.30～-0.14),差异有统计学意义(P＜0.01)；采用固定效应模型分析二者延缓学龄儿童近视眼轴长度进展量的加权均数差为-0.08 mm(95％CI:-0.11～-0.04)(P＜0.01)；采用固定效应模型分析二者延缓玻璃体腔长度进展量的加权均数差为-0.10 mm(95％CI:-0.15～-0.04)(P=0.0004).结论和单焦点眼镜相比,渐进镜能够显著延缓学龄儿童近视的屈光度进展,同时可显著延缓眼轴长度和玻璃体腔长度的增长.
목적 비교점진경화단초점안경재연완학령인동근시진전중적효과.방법 Meta분석.계통검색전자수거고Medline、EMBASE、Cochrane Library、중국생물의학문헌수거고화중국림상시험주책중심중관우점진경적수궤대조연구,수공검색상관서적기간,쌍인독립사선평고문헌화진행수거제취,이굴광도변화량、안축장도변화량화파리체강장도변화량위결국변량진행Meta분석.결과 총공유5항부합표준적수궤대조연구피납입Meta분석,총양본량위1077례.대비점진경화단초점안경채용고정효응모형분석,이자재연완학령인동근시적굴광도진전량적가권균수차위-0.22 D(95％CI:-0.30～-0.14),차이유통계학의의(P＜0.01)；채용고정효응모형분석이자연완학령인동근시안축장도진전량적가권균수차위-0.08 mm(95％CI:-0.11～-0.04)(P＜0.01)；채용고정효응모형분석이자연완파리체강장도진전량적가권균수차위-0.10 mm(95％CI:-0.15～-0.04)(P=0.0004).결론 화단초점안경상비,점진경능구현저연완학령인동근시적굴광도진전,동시가현저연완안축장도화파리체강장도적증장.
Objective To compare the effects of progressive addition lenses versus single vision lenses in slowing myopia progression in school-aged children.Methods In this meta-analysis,Medline, EMBASE, Cochrane Library, Chinese Biomedical Database and Chinese Clinical Trial Registry were systematically retrieved combined with hand searches of related journals and books for randomized clinical trial on progressive addition lenses.Two reviewers independently screened and evaluated the literatures, and extracted the data from the retrieved studies.Changes in refraction,axial length and vitreous chamber depth that were reported in randomized clinical trials were used as outcome measured for mata-analysis.Results A total of 5 randomized clinical trials meeting the inclusion criteria were included in this meta-analysis.The total sample size was 1077.Compared to single vision lenses, progressive addition lenses showed a weighted mean difference of -0.22 D (95％CI:-0.30～-0.14) for change in myopia in school-aged children using a fixed effect model.The difference was statistically significant (P＜0.01).There was a weighted mean change of axial length difference of -0.08 mm (95％CI:-0.11～-0.04) between these two methods (P＜0.01) using a fixed effect model,and a weighted mean difference of -0.10 mm (95％CI:-0.15～-0.04)(P=0.0004) using a fixed effect model.Conclusion Compared with single vision lenses, progressive addition lenses can significantly slow the progression of refractive error, axial length and vitreous chamber depth in school-aged children.