CAJ | 학술논문

目的探讨鼠抗人单克隆抗体预防及治疗尸肾移植后排斥反应的效果.方法总结和分析了62例.肾移植后应用鼠抗人单克隆抗体WuT3、WuT4预防及治疗排斥反应的效果、单克隆抗体治疗期间血清游离单克隆抗体水平与受者抗鼠抗体的产生等情况.结果该抗体对急性排斥反应的总体治愈率为76.1%,对耐激素的难治性排斥反应的逆转率达60.7%;CD3和CIN的抑制效应与血清游离单克隆抗体浓度密切相关;首次应用单克隆抗体治疗时,抗体的产生与否及量的多少并不影响疗效;在单克隆抗体治疗的过程中,CIN/CD8下降明显者,排斥逆转的可能性大;停止治疗后T淋巴细胞亚群未恢复正常水平者,感染率明显上升.结论 WuT3、WuT4对肾移植后急性排斥反应,包括耐激素急性排斥反应具有较为满意的治疗效果.
목적 탐토서항인단극륭항체예방급치료시신이식후배척반응적효과.방법 총결화분석료62례.신이식후응용서항인단극륭항체WuT3、WuT4예방급치료배척반응적효과、단극륭항체치료기간혈청유리단극륭항체수평여수자항서항체적산생등정황.결과 해항체대급성배척반응적총체치유솔위76.1%,대내격소적난치성배척반응적역전솔체60.7%;CD3화CIN적억제효응여혈청유리단극륭항체농도밀절상관;수차응용단극륭항체치료시,항체적산생여부급량적다소병불영향료효;재단극륭항체치료적과정중,CIN/CD8하강명현자,배척역전적가능성대;정지치료후T림파세포아군미회복정상수평자,감염솔명현상승.결론 WuT3、WuT4대신이식후급성배척반응,포괄내격소급성배척반응구유교위만의적치료효과.
Objective To evaluate the efficacy of McAb-T3 and McAb-T4 in renal graft rejection.Methods The data of 62 case-times receiving McAb-T3 and McAb-T4 for preventing and treating rejection in renal graft recipients were studied retrospectively,including the soluble monoclonal antibody,the humoral antibody response to a murine monoclonal antibody and T-lymphocyte subsets.Resuits The total cured rate for acute reiection was 76.1%.The reverse of steroid-resistant rejection was 60.7%.No correlation between preexisting antibodies and the severity of side effects from monoclonal therapy existed.During the treatment of McAb,the rejection reversion was probable in the patients with markedly decrease of CD4/CD8.If the T lymphocyte subsets didn't return to normal,the infectious rate was obviously increased.Conclusion MeAb-T3 and McAE-T4 had satisfactory therapeutic effects on acute rejection following renal transplantation.