CAJ | 학술논문

目的观察控释地诺前列酮用于足月胎膜早破引产的安全性及有效性.方法将2009年6至12月我院胎膜早破孕妇115例分成2组,地诺前列酮组45例,孕妇使用控释地诺前列酮引产,缩宫素组70例孕妇使用缩宫素引产,记录2组孕妇的分娩方式、产程情况、产后出血量、新生儿体重及新生儿生物物理评分.结果地诺前列酮组引产失败率2.2%(1例),缩宫素组为11.4%(8例),2组对比差异有统计学意义(P＜0.05);地诺前列酮组胎儿窘迫发生率8.9%(4例),缩宫素组为21.4%(15例),2组比较差异有统计学意义(P＜0.05);缩宫素组的剖宫产率较高[54.3%(38例)比28.9%(13例),P＜0.01];地诺前列酮组的第一产程较缩宫素组明显缩短;但地诺前列酮组发生宫缩过度刺激的比例较缩宫素组高;产后出血、新生儿窒息率2组差异无统计学意义.结论控释地诺前列酮用于足月胎膜早破引产成功率较高,可以缩短产程,不增加产后出血及新生儿窒息率,但要注意宫缩过度刺激情况.
목적 관찰공석지낙전렬동용우족월태막조파인산적안전성급유효성.방법 장2009년6지12월아원태막조파잉부115례분성2조,지낙전렬동조45례,잉부사용공석지낙전렬동인산,축궁소조70례잉부사용축궁소인산,기록2조잉부적분면방식、산정정황、산후출혈량、신생인체중급신생인생물물리평분.결과 지낙전렬동조인산실패솔2.2%(1례),축궁소조위11.4%(8례),2조대비차이유통계학의의(P＜0.05);지낙전렬동조태인군박발생솔8.9%(4례),축궁소조위21.4%(15례),2조비교차이유통계학의의(P＜0.05);축궁소조적부궁산솔교고[54.3%(38례)비28.9%(13례),P＜0.01];지낙전렬동조적제일산정교축궁소조명현축단;단지낙전렬동조발생궁축과도자격적비례교축궁소조고;산후출혈、신생인질식솔2조차이무통계학의의.결론 공석지낙전렬동용우족월태막조파인산성공솔교고,가이축단산정,불증가산후출혈급신생인질식솔,단요주의궁축과도자격정황.
Objective To explore the efficacy and safety of continuously released dinoprostone used for induction of full-term premature rupture of membranes. Methods This study recruited 115 full-term premature rupture of membranes from June 2009 to December 2009. They were divided into tow groups: the dinoprostone group (45 cases) and the oxytocin group(70 cases). The modes of delivery, stage of labor, cesarean section rate, postpartum hemorrhage, fetal and neonatal condition were analyzed. Results The failure rate of induction induced by dinoprostone was 2.2%. The failure rate of oxytocin was 11.4%. The difference reached statistical significant difference ( P = 0.020), as was the rate of fetal distress(8.9% vs 21.4% ) and the cesarean section rate(28.9% vs 54.4% ). And delivery was shortened obviously in dinoprostone group than that in oxytocin group. The over stimulation of uterine contraction occurred in dinoprostone group. There was no significant difference between 2 groups in postpartum hemorrhage and neonatal conditions. Conclusions Dinoprostone increases the success rate of induction in full-term premature rupture of membranes and shortened the delivery time. Dinoprostone does not result in postpartum hemorrhage or neonatal distress. The over stimulation of uterine contraction should be taken into account when dinoprostone is used for induction of full-term premature rupture of membranes.