中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
2期
32-34
,共3页
蓝育青%彭蔚%肖剑晖%郭慧%张弛
藍育青%彭蔚%肖劍暉%郭慧%張弛
람육청%팽위%초검휘%곽혜%장이
系统性红斑狼疮%干眼%干燥综合征%相关性
繫統性紅斑狼瘡%榦眼%榦燥綜閤徵%相關性
계통성홍반랑창%간안%간조종합정%상관성
Systemic lupus erythematomous%Dry eye%Sjogren syndrome%And correlation
目的 研究系统性红斑狼疮、干燥综合征和干眼的关系,探讨干眼严重程度与系统性红斑狼疮病情活动度的相关性.方法 回顾性分析本院2006年1月至2008年12月风湿内科住院的138例系统性红斑狼疮患者病历资料,干眼指标取SCH、BUT、FL,系统性红斑狼疮活动度指标取抗双链DNA抗体(anti-dsDNA)滴度、补体C3、C4.对其进行相关性统计分析.结果 约10%的系统性红斑狼疮患者继发干燥综合征,其干眼严重度与系统性红斑狼疮活动度有相关性,其中抗dsDNA滴度和BUT(r=-0.581,P=0.011)、抗dsDNA滴度和SCH(r=-0.819,P=0.0001)呈负相关,抗dsDNA滴度和FL呈正相关(r=0.526,P=0.025);C3和SCH呈负相关(r=10.568,P:0.014);C4和SCH(r=-0.465,P=0.052)呈弱相关.非继发干燥综合征患者干眼与系统性红斑狼疮活动度无相关性(P>0.1).结论 干燥综合征和非干燥综合征干眼的发病机制可能不同,系统性红斑狼疮继发干燥综合征的干眼患者,其干眼程度与系统性红斑狼疮活动度有相关性.
目的 研究繫統性紅斑狼瘡、榦燥綜閤徵和榦眼的關繫,探討榦眼嚴重程度與繫統性紅斑狼瘡病情活動度的相關性.方法 迴顧性分析本院2006年1月至2008年12月風濕內科住院的138例繫統性紅斑狼瘡患者病歷資料,榦眼指標取SCH、BUT、FL,繫統性紅斑狼瘡活動度指標取抗雙鏈DNA抗體(anti-dsDNA)滴度、補體C3、C4.對其進行相關性統計分析.結果 約10%的繫統性紅斑狼瘡患者繼髮榦燥綜閤徵,其榦眼嚴重度與繫統性紅斑狼瘡活動度有相關性,其中抗dsDNA滴度和BUT(r=-0.581,P=0.011)、抗dsDNA滴度和SCH(r=-0.819,P=0.0001)呈負相關,抗dsDNA滴度和FL呈正相關(r=0.526,P=0.025);C3和SCH呈負相關(r=10.568,P:0.014);C4和SCH(r=-0.465,P=0.052)呈弱相關.非繼髮榦燥綜閤徵患者榦眼與繫統性紅斑狼瘡活動度無相關性(P>0.1).結論 榦燥綜閤徵和非榦燥綜閤徵榦眼的髮病機製可能不同,繫統性紅斑狼瘡繼髮榦燥綜閤徵的榦眼患者,其榦眼程度與繫統性紅斑狼瘡活動度有相關性.
목적 연구계통성홍반랑창、간조종합정화간안적관계,탐토간안엄중정도여계통성홍반랑창병정활동도적상관성.방법 회고성분석본원2006년1월지2008년12월풍습내과주원적138례계통성홍반랑창환자병력자료,간안지표취SCH、BUT、FL,계통성홍반랑창활동도지표취항쌍련DNA항체(anti-dsDNA)적도、보체C3、C4.대기진행상관성통계분석.결과 약10%적계통성홍반랑창환자계발간조종합정,기간안엄중도여계통성홍반랑창활동도유상관성,기중항dsDNA적도화BUT(r=-0.581,P=0.011)、항dsDNA적도화SCH(r=-0.819,P=0.0001)정부상관,항dsDNA적도화FL정정상관(r=0.526,P=0.025);C3화SCH정부상관(r=10.568,P:0.014);C4화SCH(r=-0.465,P=0.052)정약상관.비계발간조종합정환자간안여계통성홍반랑창활동도무상관성(P>0.1).결론 간조종합정화비간조종합정간안적발병궤제가능불동,계통성홍반랑창계발간조종합정적간안환자,기간안정도여계통성홍반랑창활동도유상관성.
Objective To evaluate the incidence of dry eye in systemic lupus erythematomous (SLE) patients with or without sjogren syndrome (SS), and to investigate the correlation between dry eye and SLE activ-ity. Methods The records of 138 SLE patients in the department of rheumatology between Jan 1st,2006 and Dec 30 th ,2008 were reviewed. The severity of dry eye was assessed by the Schirmer test(SCH), tear film break up time (BUT), fluorescein staining (FL). The SLE activity was evaluated by the titre of anti-dsDNA, C3, and CA. The relationship of all indexes was analyzed. Results About ten percent of patients met the criteria for SS. In SS patients positive correlations were observed between anti-dsDNA titre and BUT(r = 4). 581 P =0. 011, < 0. 05), anti-dsDNA titre and SCH (r = -0. 819 P = 0. 000, < 0. 01), anti-dsDNA titre and FL (r = 0. 526 P = 0. 025, < 0.05), C3 and SCH (r = 4). 568, P = 0. 014, < 0. 05) A weak correlation between CA and SCH (r = -0. 465 P = 0. 052 < 0. 1). ; No such correlations were observed in the non-SS patients. Conclusion The patho-genesis of dry eye may be different in SS patients and non-SS patients. There were some correlations between dry eye and systemic lupus erythematomous activity in SS patients.
