外周血CD4+CD25+调节性T细胞在Graves病发病中的作用
외주혈CD4+CD25+조절성T세포재Graves병발병중적작용
On the role of peripheral blood CD4+CD25+ regulatory T cells in the pathogenesis of Graves' disease
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2012年 6期 499-500 ,共2页

    查兵兵%刘军%洪晓武%查英%王芳%盛励%丁和远%陈灶萍%徐炯

    사병병%류군%홍효무%사영%왕방%성려%정화원%진조평%서형

    格雷夫斯病%CD4+CD25+调节性T细胞%Foxp3 格雷伕斯病%CD4+CD25+調節性T細胞%Foxp3
    격뢰부사병%CD4+CD25+조절성T세포%Foxp3
    Graves' disease%CD4+ CD25+ regulatory T cells%Foxp3
    测定不同阶段Graves病患者外周血中淋巴细胞亚群含量及CD4+ CD25+调节性T细胞功能.结果显示CD4+ CD25+调节性T细胞免疫功能减弱导致CD4+T细胞增殖失控可能是Graves病发病的重要原因,药物治愈患者其免疫功能难以完全恢复正常导致Grares病容易复发.
    측정불동계단Graves병환자외주혈중림파세포아군함량급CD4+ CD25+조절성T세포공능.결과현시CD4+ CD25+조절성T세포면역공능감약도치CD4+T세포증식실공가능시Graves병발병적중요원인,약물치유환자기면역공능난이완전회복정상도치Grares병용역복발.
    Lymphocyte subsets in peripheral blood and function of CD4+CD25+ regulatory T cells(Tregs) were assayed in patients during different periods of Graves' disease ( GD ).Breakdown of Tregs' function lead to the wild proliferation of CD4+T lymphocyte,and may play an important role in the pathogenesis of GD.It is difficult to fully restore the Tregs' function to normal after successful medication in Graves' disease,this phenomenon may lead to easy relapse of GD.
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