CAJ | 학술논문

目的建立兔的股骨远端中心型骺板缺损后骨桥切除的动物模型,并对骨桥切除后的效果进行评价.方法选用日本大耳白兔10只,观察β-TCP与骨组织相容性及对骨桥生长影响.另取30只日本大耳白兔,分为A组(β -TCP标记+骨桥切除+脂肪填塞)、B组(β-TCP标记+骨桥切除)、C组(单纯缺损),每组10只,评价β -TCP标记,导针引导的方法切除骨桥的手术效果.结果 β-TCP置入后组织相容性良好,对骺板缺损后股骨畸形的程度没有影响(P＞0.05)；标记侧股骨长度(85.29 ±4.73) mm,外翻角度(12.35 ±2.53)°；未标记侧分别为(84.34 ±2.76) mm,(12.52±3.26)°.通过β-TCP标记,导针引导的方法可完整切除骨桥.运用脂肪筋膜瓣填塞骨桥切除后的缺损,可减轻股骨畸形的程度(P＜0.01).A、B、C组的股骨短缩程度分别为(4.20±1.36)、(10.26±3.31)、(6.52±1.62) mm；外翻角的差异分别为(12.00±2.11)°、(23.47±4.06)°、(18.38±10.65)°.结论通过β-TCP标记,导针引导的方法可建立兔股骨远端中心型骺板缺损后骨桥切除的标准动物模型.
목적 건립토적고골원단중심형후판결손후골교절제적동물모형,병대골교절제후적효과진행평개.방법 선용일본대이백토10지,관찰β-TCP여골조직상용성급대골교생장영향.령취30지일본대이백토,분위A조(β -TCP표기+골교절제+지방전새)、B조(β-TCP표기+골교절제)、C조(단순결손),매조10지,평개β -TCP표기,도침인도적방법절제골교적수술효과.결과 β-TCP치입후조직상용성량호,대후판결손후고골기형적정도몰유영향(P＞0.05)；표기측고골장도(85.29 ±4.73) mm,외번각도(12.35 ±2.53)°；미표기측분별위(84.34 ±2.76) mm,(12.52±3.26)°.통과β-TCP표기,도침인도적방법가완정절제골교.운용지방근막판전새골교절제후적결손,가감경고골기형적정도(P＜0.01).A、B、C조적고골단축정도분별위(4.20±1.36)、(10.26±3.31)、(6.52±1.62) mm；외번각적차이분별위(12.00±2.11)°、(23.47±4.06)°、(18.38±10.65)°.결론 통과β-TCP표기,도침인도적방법가건립토고골원단중심형후판결손후골교절제적표준동물모형.
Objective To build the animal model of bone bridge resection in rabbits after making the center epiphyseal plate defects of distal femur and to evaluate the effectiveness of bone bridge resection.Methods The histocompatibility of β3-TCP and its impact on the growth of bone bridge were observed in 10 Japanese white rabbits.The other 30 Japanese white rabbits were divided into three groups ( n =10 for each):Group A ( β-TCP marker,bone bridge resection and fat filling),Group B ( β-TCP marker and bone bridge resection) and Group C (simple defect).The effect of bone bridge resection by the marker of β-TCP and the guidance of guide pin was evaluated.Results β-TCP had good biocompatibility after implantation and did not affect the degree of femoral deformity (P ＞ 0.05).The average length of marked side' s femur was ( 85.29 ± 4.73 ) mm and the average valgus angle was ( 12.35 ± 2.53 ) °.The unmarked sides were (84.34 ±2.76) mm and ( 12.52 ±3.26)° respectively.By the marker of β-TCP and the guidance of guide pin,the bone bridge was removed completely.It reduced the degree of femoral deformity thatthe defects after bone bridge resection were filled with fat-fascia flap (P ＜ 0.01 ).The femur shortening lengths of group A,B and C were (4.20 ± 1.36),( 10.26 ± 3.31 ),(6.52 ± 1.62) mm respectively,and the differences of valgus angles were ( 12.00 ± 2.11 ) °,(23.47 ± 4.06) °,( 18.38 ± 10.65 ) °.Conclusion The classic animal model of bone bridge resection in rabbits after making the center epiphyseal plate defects of distal femur can be established by the marker of β-TCP and the guidance of guide pin.