CAJ | 학술논문

目的探讨Ang-2、MMP-2表达与乳腺癌临床病理特征的关系,分析二者表达的相关性.方法采用免疫组化SABC法检测46例乳腺浸润性导管癌和10例乳腺纤维腺瘤组织中Ang-2、MMP-2的表达水平.结果 46例乳腺癌组织中Ang-2、MMP-2表达阳性率分别为56.5%、73.9%,高于乳腺纤维腺瘤.Ang-2、MMP-2的表达水平与乳腺癌组织学分级显著相关;腋窝淋巴结转移组Ang-2、MMP-2表达阳性率高于无转移组.Ang-2、MMP-2的表达相互之间显著相关.结论乳腺癌组织中Ang-2、MMP-2表达上调,在乳腺癌发生、发展过程中具有重要作用.Ang-2、MMP-2协同刺激乳腺癌血管生成,可能是促进乳腺癌发生转移的重要机制.Ang-2可能成为判断乳腺癌预后的重要指标.
목적 탐토Ang-2、MMP-2표체여유선암림상병리특정적관계,분석이자표체적상관성.방법 채용면역조화SABC법검측46례유선침윤성도관암화10례유선섬유선류조직중Ang-2、MMP-2적표체수평.결과 46례유선암조직중Ang-2、MMP-2표체양성솔분별위56.5%、73.9%,고우유선섬유선류.Ang-2、MMP-2적표체수평여유선암조직학분급현저상관;액와림파결전이조Ang-2、MMP-2표체양성솔고우무전이조.Ang-2、MMP-2적표체상호지간현저상관.결론 유선암조직중Ang-2、MMP-2표체상조,재유선암발생、발전과정중구유중요작용.Ang-2、MMP-2협동자격유선암혈관생성,가능시촉진유선암발생전이적중요궤제.Ang-2가능성위판단유선암예후적중요지표.
Objective: To investigate the expressions of Ang-2 and MMP-2 in breast cancer and its correlations with clinicopathological characteristics, and to analyze the association of Ang-2 and MMP-2 in breast cancer. Methods: Expres-sions of Ang-2 and MMP-2 in 46 breast invasive ductal carcinoma and 10 breast fibroadenoma spicemens were detected by immunohistochemical method (SABC). Results: Ang-2 and MMP-2 positive expression rates were 56.5% and 73.9% in 46 breast carcinomas respectively, which were significantly higher than those in breast fibroadenomas. In high histological grade diseases Ang-2 and MMP-2 positive rates were significantly higher than those in low grade diseases. Ang-2 and MMP-2 positive expressions were associated with axillary lymph node metastases. Significant correlations were found between Ang-2 and MMP-2 expressions. Conclusion: Ang-2 and MMP-2 over-expressions in breast caicinoma are significantly corre-lated with occurrence, development of breast cancer. Ang-2, MMP-2 cooperate in promoting the vascular growth of breast cancer. Ang-2 might serve as a valuable prognostic indicator in breast cancer.