复旦学报（医学版）
複旦學報（醫學版）
복단학보（의학판）
FUDAN UNIVERSITY JOURNAL OF MEDICAL SCIENCES
2009年
6期
757-759
,共3页
磁场%超氧化物歧化酶%丙二醛%一氧化氮
磁場%超氧化物歧化酶%丙二醛%一氧化氮
자장%초양화물기화매%병이철%일양화담
magnetic field%superoxide dismutase%malondialdehyde%nitric oxide
目的 探讨围术期磁场环境对行经蝶垂体瘤切除手术患者的血清超氧化物歧化酶(superoxide dismutase,SOD)活力、丙二醛(malon-dialdehyde,MDA)及一氧化氮(nitric oxide,NO)含量的影响.方法 选取16例经蝶垂体瘤切除患者,ASA Ⅰ或Ⅱ级,随机分为曝磁组(M组)和对照组(C组),每组8例.M组围术期曝露在150 mT磁场环境下,C组围术期则未曝露在磁场环境下.两组分别于诱导前(T_0)、诱导后即刻(T1)、诱导后70 min(磁场暴露60 min) (T_2)及诱导后130 min(磁场暴露120 min) (T_3)抽取动脉血,测定血清SOD活力、MDA和NO含量.结果 在150 mT的磁场暴露120 min后曝磁组的血清SOD活力高于对照组(P<0.05),曝磁组的血清MDA含量低于对照组(P<0.05),同时曝磁组的NO含量高于对照组(P<0.05).结论 磁场可以使经蝶垂体瘤切除术患者的血清SOD活力和NO含量增加并降低其MDA含量.
目的 探討圍術期磁場環境對行經蝶垂體瘤切除手術患者的血清超氧化物歧化酶(superoxide dismutase,SOD)活力、丙二醛(malon-dialdehyde,MDA)及一氧化氮(nitric oxide,NO)含量的影響.方法 選取16例經蝶垂體瘤切除患者,ASA Ⅰ或Ⅱ級,隨機分為曝磁組(M組)和對照組(C組),每組8例.M組圍術期曝露在150 mT磁場環境下,C組圍術期則未曝露在磁場環境下.兩組分彆于誘導前(T_0)、誘導後即刻(T1)、誘導後70 min(磁場暴露60 min) (T_2)及誘導後130 min(磁場暴露120 min) (T_3)抽取動脈血,測定血清SOD活力、MDA和NO含量.結果 在150 mT的磁場暴露120 min後曝磁組的血清SOD活力高于對照組(P<0.05),曝磁組的血清MDA含量低于對照組(P<0.05),同時曝磁組的NO含量高于對照組(P<0.05).結論 磁場可以使經蝶垂體瘤切除術患者的血清SOD活力和NO含量增加併降低其MDA含量.
목적 탐토위술기자장배경대행경접수체류절제수술환자적혈청초양화물기화매(superoxide dismutase,SOD)활력、병이철(malon-dialdehyde,MDA)급일양화담(nitric oxide,NO)함량적영향.방법 선취16례경접수체류절제환자,ASA Ⅰ혹Ⅱ급,수궤분위폭자조(M조)화대조조(C조),매조8례.M조위술기폭로재150 mT자장배경하,C조위술기칙미폭로재자장배경하.량조분별우유도전(T_0)、유도후즉각(T1)、유도후70 min(자장폭로60 min) (T_2)급유도후130 min(자장폭로120 min) (T_3)추취동맥혈,측정혈청SOD활력、MDA화NO함량.결과 재150 mT적자장폭로120 min후폭자조적혈청SOD활력고우대조조(P<0.05),폭자조적혈청MDA함량저우대조조(P<0.05),동시폭자조적NO함량고우대조조(P<0.05).결론 자장가이사경접수체류절제술환자적혈청SOD활력화NO함량증가병강저기MDA함량.
Objective To study the effect of magnetic field on serum activity of superoxide dismutase (SOD), content of malon-dialdehyde (MDA)and content of nitric oxide (NO)in patients undergoing operation for pituitary Tumor. Methods Sixteen ASA Ⅰor Ⅱ patients undergoing pituitary tumor surgery under general anesthesia were randomly divided into 2 groups (n=8 each): magnetic field group (M) and control group (C). Patients in magnetic field group were exposed in 150 mT magnetic field during the operation period.Blood samples were taken from radial artery for determination of serum SOD,MAD and NO before induction of anesthesia(T_0, baseline),after induction(T_1),70 min after induction(exposed in magnetic field for 60 min) (T_2)and 130 min after induction (exposed in magnetic field for 120 min) (T_3). Results There was no significant difference between the two groups in age, sex (M/F ratio),body weight,body height,duration of operation and duration of anaesthesia.The serum activity of SOD and content of NO were significantly higher at T_3 in group M than that in group C,and the serum content of MDA was lower at T_3 in group M than that in group C. Conclusions The magnetic field not only increases serum SOD activity and the content of NO in patient undergoing operation for pituitary tumor,but also reduces the content of MDA in them.
