华中科技大学学报（医学版）
華中科技大學學報（醫學版）
화중과기대학학보（의학판）
ACTA UNIVERSITATIS MEDICINAE TONGJI
2009年
6期
821-823
,共3页
付圣灵%廖永德%游良琨%曾敏%邢昕%竹向宁
付聖靈%廖永德%遊良琨%曾敏%邢昕%竹嚮寧
부골령%료영덕%유량곤%증민%형흔%죽향저
非小细胞肺癌%胰岛素样生长因子-I%酶联免疫吸附实验
非小細胞肺癌%胰島素樣生長因子-I%酶聯免疫吸附實驗
비소세포폐암%이도소양생장인자-I%매련면역흡부실험
non-small cell lung cancer%insulin-like growth factor-I%enzyme linked immunosorbent assay
目的 探讨循环血胰岛素样生长因子-I(IGF-I)在非小细胞肺癌(NSCLC)发展中的作用及其临床意义.方法 运用双抗夹心酶联免疫吸附反应定量检测80例原发性NSCLC患者和45例肺良性疾病患者循环血中IGF-I,分析循环血IGF-I水平与I临床病理特征的相关性.结果 NSCLC组循环血IGF-I水平显著高于肺良性疾病组;NSCLC患者循环血中IGF-I水平在肿瘤直径≥3cm组显著高于直径<3cm组,在伴局部淋巴结转移组显著高于无局部淋巴结转移组,在晚期(HI～Ⅳ)组显著高于早期(I～Ⅱ)组.结论 IGF-I可能以自分泌和/或旁分泌的方式促进NSCLC恶性进展.其自分泌和/或旁分泌水平与肿瘤大小、病理分期和淋巴结转移相关,体积大、分期晚、伴淋巴结转移的肺癌能分泌更多的IGF-I.检测循环血IGF-I水平对辅助判断NSCLC的分期可能有应用前景.
目的 探討循環血胰島素樣生長因子-I(IGF-I)在非小細胞肺癌(NSCLC)髮展中的作用及其臨床意義.方法 運用雙抗夾心酶聯免疫吸附反應定量檢測80例原髮性NSCLC患者和45例肺良性疾病患者循環血中IGF-I,分析循環血IGF-I水平與I臨床病理特徵的相關性.結果 NSCLC組循環血IGF-I水平顯著高于肺良性疾病組;NSCLC患者循環血中IGF-I水平在腫瘤直徑≥3cm組顯著高于直徑<3cm組,在伴跼部淋巴結轉移組顯著高于無跼部淋巴結轉移組,在晚期(HI～Ⅳ)組顯著高于早期(I～Ⅱ)組.結論 IGF-I可能以自分泌和/或徬分泌的方式促進NSCLC噁性進展.其自分泌和/或徬分泌水平與腫瘤大小、病理分期和淋巴結轉移相關,體積大、分期晚、伴淋巴結轉移的肺癌能分泌更多的IGF-I.檢測循環血IGF-I水平對輔助判斷NSCLC的分期可能有應用前景.
목적 탐토순배혈이도소양생장인자-I(IGF-I)재비소세포폐암(NSCLC)발전중적작용급기림상의의.방법 운용쌍항협심매련면역흡부반응정량검측80례원발성NSCLC환자화45례폐량성질병환자순배혈중IGF-I,분석순배혈IGF-I수평여I림상병리특정적상관성.결과 NSCLC조순배혈IGF-I수평현저고우폐량성질병조;NSCLC환자순배혈중IGF-I수평재종류직경≥3cm조현저고우직경<3cm조,재반국부림파결전이조현저고우무국부림파결전이조,재만기(HI～Ⅳ)조현저고우조기(I～Ⅱ)조.결론 IGF-I가능이자분비화/혹방분비적방식촉진NSCLC악성진전.기자분비화/혹방분비수평여종류대소、병리분기화림파결전이상관,체적대、분기만、반림파결전이적폐암능분비경다적IGF-I.검측순배혈IGF-I수평대보조판단NSCLC적분기가능유응용전경.
Objective To explore the role of circulating insulin-like growth factor-I(IGF-I) in non-small cell lung cancer'(NSCLC)progression and its clinical significance.Methods Blood circulating IGF-I levels in 80 patients with NSCLC and 45 patients with benign pulmonary diseases were measured by using enzyme linked immunosorbent assay(ELISA) and the relationship between IGF-I level and clinicopathological parameters was analyzed.Results Blood circulating IGF-I level was significantly higher in patients with NSCLC than in those with benign pulmonary diseases.Blood circulating IGF-I was significantly higher in patients with NSCLC with advanced stages(stages Ⅲ and IV)or with the tumor diameter no less than 3 cm or with regional lymphoid node metastasis than in those with early stages(stages I or II) or with the tumor diameter less than 3 cm or without regional lymphoid node metastasis.Conclusion IGF-I may promote malignant progression of NSCLC in autocrine and/or paracrine manner.The autocrine and/or paracrine level of IGF-I is correlated with tumor diameter,tumor stage and regional lymphoid node metastasis.NSCLC with advanced stages,larger size and regional lymphoid node metastasis may secret more IGF-I.Measurement of circulating IGF-I may have clinical value to assess stages of NSCLC.
